In:
Clinical Nuclear Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 43, No. 6 ( 2018-6), p. 396-401
Kurzfassung:
Whereas SPECT images obtained 180 minutes after administration of 123 I-iomazenil (IMZ) (late images) are proportional to the distribution of central benzodiazepine receptor–binding potential, SPECT images obtained within 30 minutes after 123 I-IMZ administration (early images) correlate with regional brain perfusion. The aim of the present study was to determine whether crossed cerebellar tracer uptake on acute-stage 123 I-IMZ SPECT imaging predicts 3-month functional outcome in patients with nonfatal hypertensive putaminal or thalamic hemorrhage. Methods Forty-six patients underwent early and late SPECT imaging with 123 I-IMZ within 7 days after the onset of hemorrhage. A region of interest was automatically placed in the bilateral cerebellar hemispheres using a 3-dimensional stereotaxic region-of-interest template, and the ratio of the value in the cerebellar hemisphere contralateral to the affected side to that in the ipsilateral cerebellar hemisphere (AR cbl ) was calculated in each patient. Each patient's physical function was measured using the modified Rankin scale (mRS) score 3 months after onset. Results The AR cbl on early ( ρ = −0.511, P = 0.0003) and late ( ρ = −0.714, P 〈 0.0001) images correlated with the mRS 3 months after the onset of hemorrhage. Multivariate analysis showed that only a low AR cbl in late images was significantly associated with a poor functional outcome (mRS score ≥3 at 3 months after onset) (95% confidence interval, 0.001–0.003; P = 0.0212). Conclusions Crossed cerebellar tracer uptake on acute-stage 123 I-IMZ SPECT imaging predicts 3-month functional outcome in patients with nonfatal hypertensive putaminal or thalamic hemorrhage.
Materialart:
Online-Ressource
ISSN:
1536-0229
,
0363-9762
DOI:
10.1097/RLU.0000000000002068
Sprache:
Englisch
Verlag:
Ovid Technologies (Wolters Kluwer Health)
Publikationsdatum:
2018
ZDB Id:
2045053-9
ZDB Id:
197628-X
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