In:
Angiology, SAGE Publications, Vol. 48, No. 6 ( 1997-06), p. 515-521
Abstract:
The effect of nisoldipine, a dihydropyridine Ca 2+ antagonist, on the platelet cytosolic Ca 2+ concentration ( [Ca 2+ ] i), platelet aggregation, and various coagulation and fibri nolysis parameters was assessed in normotensive patients with coronary artery disease (CAD). Eleven patients with angiographically confirmed CAD (4 men, 7 women aged 67.3 ±5.4 years) were administered nisoldipine at 10 mg/day for two weeks. The [Ca 2+ ]i was determined by use of fura2-loaded platelets, platelet aggregation was measured with an aggregometer, and coagulation/fibrinolysis parameters were measured by standard methods. Nisoldipine did not significantly affect blood pressure or heart rate. However, the [Ca 2+ ] decreased significantly (P 〈 0.05) and platelet aggregation was also signifi cantly inhibited. Plasma D-dimer levels decreased significantly (P 〈 0.01). Thus, nisol dipine not only suppressed platelet activation but also affected the coagulation system, suggesting that it is not only a vasodilator and platelet inhibitor but also an antithrom botic agent.
Type of Medium:
Online Resource
ISSN:
0003-3197
,
1940-1574
DOI:
10.1177/000331979704800606
Language:
English
Publisher:
SAGE Publications
Publication Date:
1997
detail.hit.zdb_id:
2065911-8
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