In:
Hepatology Research, Wiley, Vol. 53, No. 8 ( 2023-08), p. 713-722
Abstract:
This study aimed to elucidate a surrogate marker of sarcopenia in patients with liver cirrhosis (LC). Methods A total of 424 patients were assessed for handgrip strength (HGS) and skeletal muscle index (SMI). They were divided into two groups: sarcopenia (Group S; n = 80) and nonsarcopenia (Group NS; n = 344). Results Group S showed significantly lower HGS, SMI, and hemoglobin (Hb) levels in males and female patients, and lower serum levels of albumin, cholinesterase, and zinc (all p 〈 0.001), along with significantly higher serum levels of procollagen type III‐N‐peptide and type IV collagen 7S‐domain ( p 〈 0.001 and p 〈 0.0017) than Group NS. The risk factors for sarcopenia were age 65 years or older, female gender, Child–Pugh class C, and Hb levels 〈 10.9 g/dL in women and 〈 12.4 g/dL in men ( p = 0.012, p 〈 0.001, p = 0.031, and p 〈 0.001, respectively). Significant positive correlations were found between the Hb level and the SMI and HGS ( r = 0.4, p 〈 0.001 and r = 0.4, p 〈 0.001, respectively). Sarcopenia, low HGS, and low SMI were significantly associated with overall survival in patients with LC (all p 〈 0.001). The predictive accuracy of Hb levels for predicting sarcopenia was significantly higher than for predicting SMI and tended to be higher than for predicting HGS ( p = 0.014 and p = 0.059, respectively). Conclusion Hemoglobin levels are predictive of sarcopenia in patients with LC and warrants further investigation as a biomarker for sarcopenia in LC.
Type of Medium:
Online Resource
ISSN:
1386-6346
,
1872-034X
Language:
English
Publisher:
Wiley
Publication Date:
2023
detail.hit.zdb_id:
2006439-1
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