In:
European Journal of Inorganic Chemistry, Wiley, Vol. 2010, No. 36 ( 2010-12), p. 5617-5628
Abstract:
New chlorido(dimethyl sulfoxide)iridium(III) complexes with N 6 ‐substituted adenine derivatives: [Ir III Cl 4 (DMSO‐κS){H‐AdeC x –κN(7)}] · n H 2 O [ x = 3, n = 3 for 1 ; x = 4, n = 0.5 and 3 for 2a and 2b , respectively; x = 5, n = 0 for 3 ; x = 10, n = 0.33 for 4 ] and [Ir III Cl 4 (DMSO‐κS){H‐AdeC x –κN(9)}] [ x = 3 for 5 ; x = 4 for 6 , x = 5 for 7 ; x = 10 for 8 ] have been synthesized and characterized by spectroscopic techniques and by single‐crystal X‐ray diffraction studies ( 1 , 2b and 5 ). In all cases, iridium shows octahedral geometry and is coordinated to four chlorido ligands and one S atom from dimethyl sulfoxide (DMSO‐κS). The coordination sphere of the metal is completed by the N 6 ‐substituted adenine molecule. Two different coordination modes are observed: (i) the ligand is protonated at N(1) and coordinated through N(7) (complexes 1 – 4 ); (ii) the adenine is protonated at N(3) and coordinated through N(9) (complexes 5 – 8 ). The kinetic/thermodynamic mechanisms that yield the different coordination products have been studied by using DFT calculations. Electrophoretic mobility studies and atomic force microscopy (AFM) investigation of the interaction between complexes 1 , 5 , 8 and plasmid pBR322 DNA have been performed.
Type of Medium:
Online Resource
ISSN:
1434-1948
,
1099-0682
DOI:
10.1002/ejic.v2010.36
DOI:
10.1002/ejic.201000821
Language:
English
Publisher:
Wiley
Publication Date:
2010
detail.hit.zdb_id:
1475009-0
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