In:
Experimental Dermatology, Wiley, Vol. 23, No. 12 ( 2014-12), p. 884-889
Abstract:
Although being a normal part of the skin flora, yeasts of the genus Malassezia are associated with several common dermatologic conditions including pityriasis versicolour, seborrhoeic dermatitis ( SD ), folliculitis, atopic eczema/dermatitis ( AE / AD ) and dandruff. While Malassezia spp. are aetiological agents of pityriasis versicolour, a causal role of Malassezia spp. in AE / AD and SD remains to be established. Previous reports have shown that fungi such as Candida albicans and Aspergillus fumigatus are able to efficiently activate the NLRP 3 inflammasome leading to robust secretion of the pro‐inflammatory cytokine IL ‐1 β . To date, innate immune responses to Malassezia spp. are not well characterized. Here, we show that different Malassezia species could induce NLRP 3 inflammasome activation and subsequent IL ‐1 β secretion in human antigen‐presenting cells. In contrast, keratinocytes were not able to secrete IL ‐1 β when exposed to Malassezia spp. Moreover, we demonstrate that IL ‐1 β secretion in antigen‐presenting cells was dependent on Syk‐kinase signalling. Our results identify Malassezia spp. as potential strong inducers of pro‐inflammatory responses when taken up by antigen‐presenting cells and identify C‐type lectin receptors and the NLRP 3 inflammasome as crucial actors in this process.
Type of Medium:
Online Resource
ISSN:
0906-6705
,
1600-0625
DOI:
10.1111/exd.2014.23.issue-12
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2026228-0
Permalink