In:
Journal of Biomedical Materials Research Part B: Applied Biomaterials, Wiley, Vol. 96B, No. 1 ( 2011-01), p. 67-75
Abstract:
Ovine forestomach matrix (OFM) is a native and functional decellularized extracellular matrix biomaterial that supports cell adhesion and proliferation and is remodeled during the course of tissue regeneration. Small angle X‐ray scattering demonstrated that OFM retains a native collagen architecture ( d spacing = 63.5 ± 0.2 nm, orientation index = 20°). The biophysical properties of OFM were further defined using ball‐burst, uniaxial and suture retention testing, as well as a quantification of aqueous permeability. OFM biomaterial was relatively strong (yield stress = 10.15 ± 1.81 MPa) and elastic (modulus = 0.044 ± 0.009 GPa). Lamination was used to generate new OFM‐based biomaterials with a range of biophysical properties. The resultant multi‐ply OFM biomaterials had suitable biophysical characteristics for clinical applications where the grafted biomaterial is under load. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2011.
Type of Medium:
Online Resource
ISSN:
1552-4973
,
1552-4981
DOI:
10.1002/jbm.b.v96b.1
Language:
English
Publisher:
Wiley
Publication Date:
2011
detail.hit.zdb_id:
2130917-6
SSG:
12
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