In:
FEBS Letters, Wiley, Vol. 237, No. 1-2 ( 1988-09-12), p. 128-132
Abstract:
The plant alkaloids castanospermine, dihydroxymethyldihydroxypyrrolidine and deoxynojirimycin have recently been shown to have potential anti‐HIV activity [(1987) Proc. Natl. Acad. Sci. USA 84, 8120–8124; (1987) Nature 330, 74–77; (1987) Lancet i, 1025–1026] . They are thought to act by inhibiting α‐glucosidase I, an enzyme involved in the processing of N ‐linked oligosaccharides on glycoproteins. We report here the relative efficacy of a spectrum of amino‐sugar derivatives as inhibition of HIV cytopathicity. Several α‐glucosidase inhibitors and α‐fucosidase inhibitors were found to be active at concentrations which were non‐cytotoxic.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/0014-5793(88)80185-6
Language:
English
Publisher:
Wiley
Publication Date:
1988
detail.hit.zdb_id:
1460391-3
SSG:
12
Permalink