In:
Journal of Biomedicine and Biotechnology, Hindawi Limited, Vol. 2012 ( 2012), p. 1-8
Abstract:
Background . Despite advancements in comprehension of molecular mechanisms governing bone marrow (BM) homing of hematopoietic stem cells, cord blood transplant (CBT) suffers from a slow rate of hematopoietic recovery. Intrabone (IB) injection has been proposed as a method able to improve speed of BM engraftment with respect to conventional IV protocols. However, the mechanisms underlying this benefit are largely unknown. Aim . To verify whether IB-CBT determines a local engraftment able to predict the reconstitution of recipient hematopoiesis. Design and Methods . Twenty-one patients with hematologic malignancies received IB injection into both iliac crests of 3.2 ± 0.68 * 107/kg cord blood cells. One month following IB-CBT, PET-CT imaging was performed. Maximal standardized uptake values (SUVs) were assessed in BM of both iliac crests and in all lumbar vertebrae. Results . Maximal SUV within iliac crests was higher than in lumbar vertebrae ( 4.1 ± 1.7 versus 3.2 ± 0.7 , resp., P = 0.01 ). However, metabolic activity in these two different BM districts was significantly correlated ( r = 0.7 , P 〈 0.001 ). Moreover, FDG uptake values within the injection site closely predicted platelet recovery 100 days after IB-CBT ( r = 0.72 , P 〈 0.01 ). Conclusions . The metabolic activity of injected BM predicts the subsequent rate of hematopoietic recovery after IB-CBT, suggesting a pivotal role of the local engraftment in the reconstitution of recipient hematopoiesis.
Type of Medium:
Online Resource
ISSN:
1110-7243
,
1110-7251
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2012
detail.hit.zdb_id:
2698540-8
detail.hit.zdb_id:
2512507-2
SSG:
12
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