In:
PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 3 ( 2023-3-28), p. e0280238-
Abstract:
In women scheduled for cancer treatment, oocytes cryopreservation is a well-established procedure. Random start protocols have been a substantial improvement in this setting, allowing to prevent delay in the initiation of cancer treatments. However, there is still the need to optimize the regimen of ovarian stimulation, to make treatments more patient-friendly and to reduce costs. Methods This retrospective study compares two periods (2019 and 2020), corresponding to two different ovarian stimulation regimens. In 2019, women were treated with corifollitropin, recombinant FSH and GnRH antagonists. Ovulation was triggered with GnRH agonists. In 2020, the policy changed, and women were treated with a progestin-primed ovarian stimulation (PPOS) protocol with human menopausal gonadotropin (hMG) and dual trigger (GnRH agonist and low dose hCG) Continuous data are reported as median [Interquartile Range]. To overcome expected changes in baseline characteristics of the women, the primary outcome was the ratio between the number of mature oocytes retrieved and serum anti-mullerian hormone (AMH) in ng/ml. Results Overall, 124 women were selected, 46 in 2019 and 78 in 2020. The ratio between the number of mature oocytes retrieved and serum AMH in the first and second period was 4.0 [2.3–7.1] and 4.0 [2.7–6.8] , respectively (p = 0.80). The number of scans was 3 [3–4] and 3 [2–3] , respectively (p 〈 0.001). The total costs of the drugs used for ovarian stimulation were 940 € [774–1,096 €] and 520 € [434–564 €] , respectively (p 〈 0.001). Conclusions Random start PPOS with hMG and dual trigger represents an easy and affordable ovarian stimulation protocol for fertility preservation in women with cancer, showing similar efficacy and being more friendly and economical.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0280238
DOI:
10.1371/journal.pone.0280238.g001
DOI:
10.1371/journal.pone.0280238.g002
DOI:
10.1371/journal.pone.0280238.g003
DOI:
10.1371/journal.pone.0280238.t001
DOI:
10.1371/journal.pone.0280238.t002
DOI:
10.1371/journal.pone.0280238.t003
DOI:
10.1371/journal.pone.0280238.s001
DOI:
10.1371/journal.pone.0280238.s002
DOI:
10.1371/journal.pone.0280238.r001
DOI:
10.1371/journal.pone.0280238.r002
DOI:
10.1371/journal.pone.0280238.r003
DOI:
10.1371/journal.pone.0280238.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2267670-3
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