In:
Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 99, No. 7 ( 2020-02), p. e19106-
Abstract:
We sought to investigate the effect of total triiodothyronine (TT 3 ) reduction in the follow-up of patients with idiopathic membranous nephropathy (IMN). A total of 121 patients were enrolled and classified into a low TT 3 group or a normal group. Clinical indicators were compared between the groups, and changes in estimated glomerular filtration rate (eGFR), albumin (ALB), thyroid-stimulating hormone, serum creatinine, total protein, total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) during follow-up were analysed. In the analysis by TT 3 level, ALB was significantly lower in the low TT 3 group ( P 〈 .05), while TC, TG, LDL-C, fibrinogen, and renal pathological staging were significantly higher in the low TT 3 group ( P 〈 .05). Analysis of variance for repeated measurement during follow-up showed that there were no significant differences in eGFR and ALB between the groups. TC, TG, and LDL-C levels were significantly higher in the low TT 3 group ( P 〈 .05). Approximately 37% of patients with IMN showed a decrease in TT 3 , which was accompanied by significantly decreased ALB level, higher pathological stage, and increased serum lipid level compared with patients having a normal TT 3 level. The management of TT 3 , and appropriate intervention, may therefore help to prevent the kidney damage progress in patients with IMN.
Type of Medium:
Online Resource
ISSN:
0025-7974
,
1536-5964
DOI:
10.1097/MD.0000000000019106
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2020
detail.hit.zdb_id:
2049818-4
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