In:
Current Rheumatology Reviews, Bentham Science Publishers Ltd., Vol. 18, No. 2 ( 2022-05), p. 160-167
Abstract:
Neutrophil to lymphocyte ratio (NLR) is a marker for many inflammatory
diseases. Ankylosing spondylitis (AS) is among these inflammatory diseases, and many studies have compared the NLR ratio between patients with AS and healthy controls. Aim: This study aims to systematically review and analyze the available evidence about the significance
of NLR values in AS. Method: Based on Meta-analysis of Observational Studies in Epidemiology (MOOSE) guidelines,
we searched Embase, Pubmed, ISI Web of Science, and Scopus databases from inception to August 2020 using (“Ankylosing spondyl* ” OR “Bechterew Disease” OR “Rheumatoid Spondylitis”)
AND ((neutrophil* AND lymphocyte*) OR NLR) as key terms of the search strategy. Data selection and extraction were conducted separately by two authors. We appraised the included articles according to the Joanna Briggs checklist. Comprehensive Meta-analysis Version 2 was used
for analysis and assessment of publication bias. I2 〉 75% and p-value 〈 0.05 were considered significant. Result: In total, 182 studies resulted from a search in all databases. Duplicate removal, title, abstract,
and full-text screening yielded 12 related studies, with 11 included in the meta-analysis. Quality assessment was satisfying in all studies. Pooled difference in NLR means value between patients
and controls was 0.38 (95% CI: 0.24-0.52, p-value 〈 0.0001). An I2 of 51% and a Cochran Q
test p-value of 〈 0.05 indicated moderate heterogeneity; thus, subgroup analysis had no indication.
Publication bias was not significant (Funnel plot with an Egger’s intercept of -0.07; p-value=0.95). Conclusion: Significant higher amounts of NLR may be strongly indicative of underlying inflammation
in AS.
Type of Medium:
Online Resource
ISSN:
1573-3971
DOI:
10.2174/1573397117666210921114431
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2022
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