In:
Personalized Medicine, Future Medicine Ltd, Vol. 18, No. 6 ( 2021-11), p. 533-540
Abstract:
Lay abstract The clinical response to statins, mainly atorvastatin and simvastatin, can be modified by interindividual variability including variations in the SLCO1B1 gene. This gene, that encodes the statin transporter OATP1B1, helps to regulate the cholesterol levels in the blood and is responsible for the presence of adverse drug reactions related to the statin consumption, such as muscular sickness. This study analyzes the distribution of the SLCO1B1 gene variants rs4149056 and rs2306283 in geographically dispersed samples of the two main populations in Mexico: two Mestizo (admixed) populations and three Native American groups. We found that the genetic combinations of T–A and T–G for the two SLCO1B1 gene variants – associated with normal or efficient activity of the transporter OATP1B – were predominant in all of the study population. Therefore, the SLCO1B1 gene variability suggests that a majority of the Mexican population will respond favorably to simvastatin and have a low risk of developing associated muscular complications.
Type of Medium:
Online Resource
ISSN:
1741-0541
,
1744-828X
DOI:
10.2217/pme-2020-0172
Language:
English
Publisher:
Future Medicine Ltd
Publication Date:
2021
SSG:
15,3
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