In:
Current Drug Delivery, Bentham Science Publishers Ltd., Vol. 20, No. 3 ( 2023-03), p. 292-305
Abstract:
The use of synthetic and semi-synthetic materials in drug delivery systems has
associated drawbacks like costly synthesis, toxicity, and biocompatibility issues. Therefore, there is a need to introduce novel materials to overcome such issues. Naturally occurring and water-swellable
polysaccharides are advantageous in overcoming the above-mentioned issues. Therefore, we are reporting a novel hydrogel (SSH) isolated from the seeds of Salvia spinosa as a sustained release material. Methods: SSH was explored for its pH-dependent and salt-responsive swelling before and after compression
in a tablet form. Stimuli-responsive swelling and deswelling were also monitored at pH 7.4 and pH 1.2 in deionized water (DW) and normal saline and DW and ethanol. The sustained-release potential
of SSH-based tablets was monitored at gastrointestinal tract (GIT) pH. The transit of SSH tablets was ascertained through an X-ray study. Results: The swelling of SSH in powder and tablet form was found in the order of DW 〉 pH 7.4 〉 pH
6.8 〉 pH 1.2. An inverse relation was found between the swelling of SSH and the concentration of the
salt solution. The SSH showed stimuli-responsive swelling and de-swelling before and after compression, indicating the unaltered nature of SSH even in a closely packed form, i.e., tablets. Sustained release
of theophylline ( 〈 80%) was witnessed at pH 6.8 and 7.4 during the 12 h study following zeroorder
kinetics, and radiographic images also showed 9 h retention in GIT. Conclusion: These investigations showed the potential of SSH as a pH-sensitive material for sustained
and targeted drug delivery.
Type of Medium:
Online Resource
ISSN:
1567-2018
DOI:
10.2174/1567201819666220509200019
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2023
SSG:
15,3
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