In:
Chemistry – A European Journal, Wiley, Vol. 18, No. 24 ( 2012-06-11), p. 7486-7492
Abstract:
With certain amounts of sodium tert ‐butoxide and tert ‐butanol as additives, catalytic amounts of an inexpensive and easy‐to‐handle copper source Cu(OAc) 2 ⋅ H 2 O, a commercially available and air‐stable non‐racemic dipyridylphosphine ligand, as well as the stoichiometric desirable hydride donor polymethylhydrosiloxane (PMHS), formed a versatile in situ catalyst system for the enantioselective reduction of a broad spectrum of prochiral diaryl and aryl heteroarylketones in air, in high yields and with good to excellent enantioselectivities (up to 96 %). In particular, the practical viability of this process was evinced by its successful applications in the asymmetric synthesis of optically enriched potent antihistaminic drugs orphenadrine and neobenodine.
Type of Medium:
Online Resource
ISSN:
0947-6539
,
1521-3765
DOI:
10.1002/chem.201200379
Language:
English
Publisher:
Wiley
Publication Date:
2012
detail.hit.zdb_id:
1478547-X
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