In:
Chemistry – A European Journal, Wiley, Vol. 27, No. 67 ( 2021-12), p. 16707-16715
Abstract:
Upconversion luminescent (UCL) triggered photodynamic therapy (PDT) affords superior outcome for cancer treatment. However, conventional UCL materials which all work by a multiphoton absorption (MPA) process inevitably need extremely high power density far over the maximum permissible exposure (MPE) to laser. Here, a one‐photon absorption molecular upconversion sensitizer Cy5.5‐Br based on frequency upconversion luminescent (FUCL) is designed for PDT. The unusual super heavy atom effect (SHAE) in Cy5.5‐Br strongly enhances its spin‐orbit coupling (0.23 cm −1 ), triplet quantum yield (11.1 %) and triplet state lifetime (18.8 μs) while the potential hot‐band absorption of Cy5.5‐Br is well maintained. Importantly, Cy5.5‐Br can efficiently target the tumour site and kill cancer cells by destroying mitochondria under a biosafety MPE to 808 nm laser. The photostability and antitumor results are obviously superior to that of a Stokes process. This work provides a design criterion for FUCL dyes to realize effective PDT upon a biosafety optical density, possibly bringing more clinical benefits than conventional MPA materials.
Type of Medium:
Online Resource
ISSN:
0947-6539
,
1521-3765
DOI:
10.1002/chem.202102866
Language:
English
Publisher:
Wiley
Publication Date:
2021
detail.hit.zdb_id:
1478547-X
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