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  • Walter de Gruyter GmbH  (3)
  • Fan, Jian  (3)
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  • Walter de Gruyter GmbH  (3)
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  • 1
    Online Resource
    Online Resource
    Chemokine receptor 9 high-expression involved in the migration and invasion of the non-small-cell lung cancer cells
    Walter de Gruyter GmbH ; 2011
    In:  Asian Biomedicine Vol. 5, No. 1 ( 2011-2-1), p. 69-76
    Details
    In: Asian Biomedicine, Walter de Gruyter GmbH, Vol. 5, No. 1 ( 2011-2-1), p. 69-76
    Abstract: Background: Metastasis is responsible for most cancer-related death, and the metastatic spread of neoplastic cells may be related to the ability of migration and invasion. Chemokine receptor 9 (CCR9) plays an important role in cutaneous melanoma and prostate cancer cells migration and invasion. Objective: Investigate the specific role of the chemokine-ligand (CCR9-CCL25) axis in the development of nonsmall cell lung cancer (NSCLC) metastasis. Methods: Semi-quantitative reverse transcriptase-PCR, western-blot, flow cytometry, migration, and invasion assays were used to examine the function of CCR9 in the NSCLC cells. Results: CCR9 was highly expressed in NSCLC patient cancer tissue. In addition, in vitro migration and invasion studies on human bronchial epithelial cells of the BEAS-2B and human squamous lung cancer cell lines NCI-H157 showed that migration in response to the CCL25 was inhibited by CCR9 antibody. Conclusion: CCR9 might play an important role in the migration and invasion of the NSCLC cells.
    Type of Medium: Online Resource
    ISSN: 1875-855X
    URL: Article
    DOI: 10.5372/1905-7415.0501.008
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2011
    detail.hit.zdb_id: 2583850-7
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Retrieval of a broken sewing needle from the sacrum aided by a permanent magnet: a case report and literature review
    Walter de Gruyter GmbH ; 2017
    In:  Open Medicine Vol. 12, No. 1 ( 2017-12-29), p. 446-449
    Details
    In: Open Medicine, Walter de Gruyter GmbH, Vol. 12, No. 1 ( 2017-12-29), p. 446-449
    Abstract: Penetrating sacral injuries are very rare, but foreign bodies that penetrate the sacrum often cause pain, cerebrospinal fluid leakage, and neurological symptoms. Careful preoperative medical and imaging examinations, determining the position of the foreign body, and surgical exploration are essential in the management of such cases. We present the case of a woman who visited our emergency department with a broken sewing needle in her sacrum. The incident occurred when the patient accidentally sat on the needle while sewing by hand. Pain while sitting was the main clinical finding after the accident. The patient was treated successfully by surgical exploration aided by a permanent magnet. At follow-up a few months later, she was symptom-free. In clinical practice physicians often encounter patients with metallic foreign bodies. Permanent magnets play an important role in the removal of metallic foreign bodies, and emergency department physicians should master the methods and techniques.
    Type of Medium: Online Resource
    ISSN: 2391-5463
    URL: Article
    DOI: 10.1515/med-2017-0063
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2017
    detail.hit.zdb_id: 2829380-0
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  • 3
    Online Resource
    Online Resource
    The relationship between human muth homolog 1 gene mutation at site 415 and sporadic colon cancers in Chinese Han population
    Walter de Gruyter GmbH ; 2010
    In:  Asian Biomedicine Vol. 4, No. 6 ( 2010-12-1), p. 923-930
    Details
    In: Asian Biomedicine, Walter de Gruyter GmbH, Vol. 4, No. 6 ( 2010-12-1), p. 923-930
    Abstract: Background: The genetic factors of colon cancer play an important role in the tumor development and growth. The incidence of colon cancers has greatly increased in China. However, few data is available for the relationship between human muth homolog 1 (hMLH1) gene mutation at site 415 and sporadic colon cancers in Chinese population. Objective: Investigate the relationship between G→C mutation in hMLH1 gene at site 415 and sporadic colon cancers in Chinese Han population. Methods: Using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing techniques, the genotype of the hMLH1 gene was analyzed at site 415 in 97 cases of sporadic colon cancer patients and 138 controls. Reverse-transcription (RT)-PCR was used to determine the level of hMLH1 mRNA expression in normal colonic mucosa of patients with different genotype. Results: The frequency of genotype C/C at the 415 site of the hMLH1 gene was significantly higher in colon cancer patients than in controls. The expression levels of hMLH1 mRNA in normal colonic mucosa were similar in colon cancer patients with different genotypes. Conclusion: G’!C mutation in hMLH1 gene at site 415 may represent a genetic factor that is associated with sporadic colon cancer in a small group of Chinese Han population.
    Type of Medium: Online Resource
    ISSN: 1875-855X
    URL: Article
    DOI: 10.2478/abm-2010-0120
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2010
    detail.hit.zdb_id: 2583850-7
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