In:
Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 98, No. 20 ( 2001-09-25), p. 11485-11490
Abstract:
We have searched for genes predisposing to bipolar disorder (BP) by
studying individuals with the most extreme form of the affected phenotype, BP-I, ascertained from the genetically isolated population
of the Central Valley of Costa Rica (CVCR). The results of a previous linkage analysis on two extended CVCR BP-I pedigrees, CR001 and CR004,
and of linkage disequilibrium (LD) analyses of a CVCR population sample of BP-I patients implicated a candidate region on 18p11.3. We further
investigated this region by creating a physical map and developing 4 new microsatellite and 26 single-nucleotide polymorphism markers for
typing in the pedigree and population samples. We report the results of fine-scale association analyses in the population sample, as well as
evaluation of haplotypes in pedigree CR001. Our results suggest a candidate region containing six genes but also highlight the
complexities of LD mapping of common disorders.
Type of Medium:
Online Resource
ISSN:
0027-8424
,
1091-6490
DOI:
10.1073/pnas.191519098
Language:
English
Publisher:
Proceedings of the National Academy of Sciences
Publication Date:
2001
detail.hit.zdb_id:
209104-5
detail.hit.zdb_id:
1461794-8
SSG:
11
SSG:
12
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