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  • Erawati, Rachma Dini  (2)
  • 1
    Online Resource
    Online Resource
    Brawijaya University ; 2020
    In:  Malang Respiratory Journal Vol. 2, No. 01 ( 2020-04-06), p. 56-61
    In: Malang Respiratory Journal, Brawijaya University, Vol. 2, No. 01 ( 2020-04-06), p. 56-61
    Abstract: Background: Thymoma is a rare neoplasm. This incident is comparable to 390 new cases reported per year. Genetic factors are believed to be one of the factors of B3 thymoma and thymus carcinoma. Multimodality of thymoma therapy (surgery, radiation and chemotherapy) gives better results.Case Report: Mr A, 29 years old, with initial diagnosis of stage IV thymoma (according to Masaoka) with SVKS then undergo debulking, followed by chemotherapy with a regimen of Cisplatin + Vincristin, Cyclophospamid, Doxorubicin, Prednison every 21 days as much as 6 times. Subjective responses indicated by reduced complaints of chest pain and loss of swelling of the right arm. Semisubjective response indicated by increase of body weight. Objective response is progressive, so can be continued with second line chemotherapy or radiotherapy.Conclusion: The prognosis of patient with well differentiated thymic carcinoma stadium iv (thymoma b3) complicated with vena cava superior syndrome was poor because of the objective response of the chemotherapy was progressive, and the relapse case was higher.
    Type of Medium: Online Resource
    ISSN: 2722-6492 , 2745-7842
    Language: Unknown
    Publisher: Brawijaya University
    Publication Date: 2020
    Location Call Number Limitation Availability
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  • 2
    In: Malang Respiratory Journal, Brawijaya University, Vol. 2, No. 01 ( 2020-04-09), p. 49-55
    Abstract: Background: Mediastinal germ cell tumors are uncommon, representing less than 1% of all malignancies. They mostly occur in young men after puberty and have a poor prognosis with over all long term survival rate 42%. Case Report: We reported a case report in Saiful Anwar Malang Hospital, Indonesia, a young man, 26 years old with an anterior mediastinum tumor and VCSS The CT scan of the chest showed an anterosuperior mediastinal mass which compress the superior vena cava. The result from transthoracic FNAB with USG guidance showed an extragonadal germ cell tumor which resemble an Embryonal Carcinoma from mediastinum. The AFP serum level was elevated. Patient underwent a radiotherapy and a surgical debulking. The biopsy showed an Endodermal Sinus Tumor (Yolk Sac). Immunohistochemical stain for cytokeratin was positive in the tumor cells while stain for CD30 was negative. These were confirming the diagnosis of primary mediastinal yolk sac tumor. Patient received a combination chemotherapy for a total 6 cycles.Conclusion: Some procedures like biopsy, tumor marker, immunohistochemical stain, could differentiate the subtype of mediastinal germ cell tumor. The multimodality treatment by combining chemotherapy with surgical therapy or radiotherapy could increase the survival outcome of patients.
    Type of Medium: Online Resource
    ISSN: 2722-6492 , 2745-7842
    Language: Unknown
    Publisher: Brawijaya University
    Publication Date: 2020
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
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