In:
International Journal of Cancer, Wiley, Vol. 134, No. 4 ( 2014-02), p. 997-1007
Abstract:
What's new? A considerable percentage of rectal cancers are resistant to preoperative chemoradiotherapy, which exposes patients to the potential side effects of both irradiation and chemotherapy without clear benefits. In this study, IL‐6‐stimulated expression levels of phosphorylated STAT3 were remarkably higher in chemoradiotherapy‐resistant colorectal cancer cell lines. RNAi‐ and small molecule‐mediated STAT3 inhibition sensitized to chemoradiotherapy in vitro in a dose‐dependent manner, which led to a profound chemoradiotherapy‐sensitization in a subcutaneous xenograft model. These results highlight a potential role of STAT3 in treatment resistance, and provide first proof of concept that STAT3 represents a promising novel molecular target for sensitizing resistant rectal cancers to chemoradiotherapy.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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