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  • 1
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    Gender differences in pain characteristics of chronic stable angina and perceived physical limitation in patients with coronary artery disease
    Ovid Technologies (Wolters Kluwer Health) ; 2003
    In:  Pain Vol. 101, No. 1 ( 2003-01), p. 45-53
    Details
    In: Pain, Ovid Technologies (Wolters Kluwer Health), Vol. 101, No. 1 ( 2003-01), p. 45-53
    Type of Medium: Online Resource
    ISSN: 0304-3959
    URL: Article
    DOI: 10.1016/S0304-3959(02)00319-6
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2003
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  • 2
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    Abstract P318: Prevalence and Trends of Type 2 Diabetes Mellitus and Prediabetes Among Community-Dwelling Heart Failure Patients in the U.S. 2005-2016: A National Health and Nutrition Examination Survey (NHANES) Analysis
    Ovid Technologies (Wolters Kluwer Health) ; 2020
    In:  Circulation Vol. 141, No. Suppl_1 ( 2020-03-03)
    Details
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 141, No. Suppl_1 ( 2020-03-03)
    Abstract: Introduction: Recent scientific statements highlight the importance of understanding the effects of the coexistence of heart failure (HF) and type 2 diabetes mellitus (T2DM) on disease management decisions and patient outcomes. Various prevalence estimates of the T2DM burden among HF patients have been reported; however, national estimates are not available. The objective of the study was to assess the prevalence and trends of T2DM (total, diagnosed, and undiagnosed) and prediabetes among community-dwelling HF patients using nationally representative data. Methods: We included 473 participants (20+ years) with a diagnosis of HF using data from the 2005-2016 NHANES survey cycles. Diagnosed T2DM was defined by self-report of a previous physician diagnosis. Undiagnosed T2DM was defined by the absence of a physician diagnosis and the presence of ≥ 1 of 3 criteria: 1) Two-hour plasma glucose (2hPG) after oral glucose tolerance test (OGTT) ≥ 200 mg/dL, 2) Hemoglobin A1c (HbA1c) ≥ 6.5%, 3) Fasting plasma glucose (FPG) ≥ 126 mg/dL. Total T2DM was defined as having diagnosed or undiagnosed T2DM. Prediabetes was defined by the absence of T2DM and the presence of ≥ 1 of 3 criteria: 1) 2hPG after OGTT of 140 mg/dL to 199 mg/dL, 2) HbA1c of 5.7% to 6.4%, 3) FPG of 100 mg/dL to 125mg/dL. We stratified estimates by age-standardized socio-demographic characteristics. Trends of the prevalence of T2DM and prediabetes were examined using logistic regressions. Results: The prevalence rates of total, diagnosed, and undiagnosed T2DM and prediabetes among HF patients were 51.4% (95% CI, 46.0%-56.7%), 37.5% (31.7%-43.6%), 13.8% (10.0%-18.2%), and 36.0% (30.2%-42.1%), respectively. The prevalence of T2DM and prediabetes did not significantly change across individual survey cycles. Conclusion: Rates of T2DM and prediabetes among community-dwelling HF patients in the U.S have been persistently high over the past decade. These findings support the need for the prevention and targeted intervention of T2DM in HF patients.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    URL: Article
    DOI: 10.1161/circ.141.suppl_1.P318
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2020
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  • 3
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    Abstract P192: Integrative Analysis of Extracellular Molecular Profiles Associated With Cardiovascular Health in Black Americans: Results From the Morehouse-Emory Cardiovascular (MECA) Center for Health Equity
    Ovid Technologies (Wolters Kluwer Health) ; 2020
    In:  Circulation Vol. 141, No. Suppl_1 ( 2020-03-03)
    Details
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 141, No. Suppl_1 ( 2020-03-03)
    Abstract: Introduction: While cardiovascular disease (CVD) morbidity and mortality is particularly pronounced among Black Americans, there is a great deal of intra-racial heterogeneity within the population. Our objective was to identify novel circulating biomarkers (extracellular miRNA and metabolites) that predict cardiovascular health (CVH) within Blacks, while providing insight into CVD pathophysiology. Hypothesis: We hypothesize that an integrative analysis of miRNA and metabolomics profiles will enable a systems biology approach to understanding CVH as defined by the American Heart Association's Life’s Simple 7 (LS7) score within Blacks. Methods: Platelet free plasma (PFP) was collected from 382 Black adults (age 53 + 10, 40% male) without known CVD living in Atlanta, GA. CVH was determined by LS7 scores calculated from measured blood pressure, blood glucose, cholesterol, body mass index (BMI), and self-reported exercise, diet, and smoking. In the discovery phase, next generation sequencing was performed on PFP samples from 20 participants with low CVH (LS7 〈 6) and 20 with high CVH (LS7 〉 10). DESeq was used to identify differentially expressed miRNAs. In the validation phase, RT-qPCR was used to assess levels of eight miRNAs in 382 samples. Spearman correlation and linear regression analyses were performed to assess ability of miRNA levels to predict LS7. High-resolution metabolomics profiling was performed on all 382 samples. Integrative analysis of miRNA, metabolomics profiles, and clinical domains of CVH (LS7) was performed using the program xMWAS to determine connectivity among these markers. Results: RNA sequencing identified 13 extracellular miRNAs differentially expressed between low CVH and high CVH (FDR 〈 0.05). Analysis of data from validation phase found the expression of four extracellular miRNAs (miRs-122, -150, -30c, -769-3p) significantly correlated with LS7. Metabolome wide association study (MWAS) identified 141 features that were differentially expressed between low and high CVH with false discovery rate of 〈 0.2: 54 features were lower in low LS7, and 87 were higher in low LS7. These metabolomics features were enriched in 19 metabolic pathways, including glutathione metabolism, alanine and aspartate metabolism, and methionine and cysteine metabolism. Integrative analysis revealed 6 clusters in which differentially expressed miRNAs, metabolites and clinical domains of CVH were connected. Conclusions: CVH in Blacks is associated with distinct extracellular miRNA and metabolomics profiles, and these molecular profiles are associated with pathways linked to vascular dysfunction. Integrative analysis revealed connectivity between miRNA-metabolome networks and clinical domains of CVH. This novel method represents an unique opportunity to gain insights into epigenetic and environmental influences on CVD disparities.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    URL: Article
    DOI: 10.1161/circ.141.suppl_1.P192
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2020
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  • 4
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    Abstract 3695: Obesity-mediated Vascular Injury Stimulates Progenitor Cell Mobilization
    Ovid Technologies (Wolters Kluwer Health) ; 2007
    In:  Circulation Vol. 116, No. suppl_16 ( 2007-10-16)
    Details
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 116, No. suppl_16 ( 2007-10-16)
    Abstract: Recent data suggest that bone marrow derived endothelial progenitor cells contribute to endothelial repair after damage. We investigated whether obesity modulates the number and function of progenitor cells, and whether lifestyle intervention with a healthy diet influences this effect. We hypothesized that obesity-mediated vascular injury stimulates progenitor cell mobilization. Methods Peripheral blood mononuclear cells were cultured on fibronectin plates for 7 days and the number of colony forming units (CFUs) with endothelial-type cells at their periphery were counted. 28 lean healthy subjects were compared with 30 overweight/obese age-and sex-matched non-smokers on a high saturated fat ( 〉 10%) American style diet. Twenty obese subjects were then randomized to receive either a Mediterranean-style (MED) diet (n=11) or the control regular American diet (n=9) for 2 months. Endothelium-dependent and -independent function was measured by brachial reactivity testing at baseline, 1 and 2 months. Results CFUs were significantly higher in overweight/obese compared to lean subjects (74±42 vs 23±10, p 〈 0.001), even after adjustment for other risk factors. When overweight/obese subjects were treated with a MED diet, CFUs reduced significantly, a change that was not observed in the controls (Table ). There was a simultaneous improvement in brachial flow-mediated vasodilation but not endothelium-independent function in the MED group. No changes were observed in controls(Table ). Conclusion Endothelial precursors are stimulated in obese compared to lean subjects. Dietary alteration to a MED diet resulted in improvement in endothelial function and reduced mobilization of endothelial precursors. These observations suggest that endothelial injury in obesity provokes a compensatory mobilization of endothelial progenitor cell population that may help repair damage to the endothelial lining.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    URL: Article
    DOI: 10.1161/circ.116.suppl_16.II_839
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2007
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  • 5
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    Abstract 15795: Connections Between the Western Diet and Inflammation in Heart Failure
    Ovid Technologies (Wolters Kluwer Health) ; 2022
    In:  Circulation Vol. 146, No. Suppl_1 ( 2022-11-08)
    Details
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 146, No. Suppl_1 ( 2022-11-08)
    Abstract: Introduction: The Western Diet (WD) is associated with deleterious processes linked with chronic disease and may play a role in the pathophysiology of heart failure (HF). Trimethylamine-N-oxide (TMAO) is a diet-linked metabolite that contributes to inflammation and is associated with higher TNF-α, especially in HF populations. The dietary inflammatory index (DII) score measures the inflammatory potential of a diet and the inflammatory effects of foods. More studies are needed to determine how the WD impacts immunological pathways and cytokines in the context of clinical and population characteristics. Purpose: The aim of this study was to explore associations between the WD, DII, TMAO, and TNF-α in Black patients living with HF. Methods: Thirty Black participants (mean age 55.3, 67.7% women) with HF were included in this study. TMAO and TNF-α levels were analyzed from dried blood spots using immunoassays. Participants completed a Food Frequency Questionnaire (FFQ) from which a DII score was derived. Food groups and nutrients, like choline, were measured with the FFQ. Sociodemographic variables were measured. Analyses included correlational and inferential statistics. Results: Mean DII score was -.38 revealing an overall anti-inflammatory diet with higher inflammatory scores among men (-.23) as compared to women (-.43). Women consumed greater kilocalories with more saturated fat, sodium, dairy, sugar, and fruit while men consumed more cholesterol, choline, proteins, alcohol, legumes, poultry, red meats, eggs, and phosphatidylcholine. DII score was negatively correlated with dietary choline (r= -.73, p 〈 .001), but did not correlate with TMAO or TNF-α. TNF-α and TMAO were positively related (r=.30, p=.057). Conclusions: This sample of well-educated HF patients from a busy HF referral center did not consume a highly pro-inflammatory diet, yet our findings provide insight for specific food groups such as those with choline. In patients with HF, it is important to monitor intake of inflammatory foods and appreciate that increasing age may play a role in the retention of dietary metabolites. Further study of these relationships in patients with HF could lead to tailored dietary educational interventions based on dietary patterns, age, and cultural relevance.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    URL: Article
    DOI: 10.1161/circ.146.suppl_1.15795
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2022
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  • 6
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    Abstract 15533: The Association Between Life’s Simple 7 and Arterial Stiffness in Black and White Women
    Ovid Technologies (Wolters Kluwer Health) ; 2022
    In:  Circulation Vol. 146, No. Suppl_1 ( 2022-11-08)
    Details
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 146, No. Suppl_1 ( 2022-11-08)
    Abstract: Background: Black women have a higher prevalence of nonideal cardiovascular health (CVH) related risk factors across most components of the American Heart Association’s Life’s Simple 7 (LS7) than White women. Due to a higher burden of CVH-related risk factors, research suggests that Black women have accelerated and higher arterial stiffness than White women. However, the association between LS7 CVH and arterial stiffness among Black and White women is unknown. Objective: To examine the association between LS7 and arterial stiffness and investigate whether race modifies this association. Methods: We examined 1,640 adult women (n=1165 White, n=475 Black) from the Morehouse-Emory Center for Health Equity and Predictive Health Institute cohorts. Carotid-femoral pulse wave velocity (cfPWV), a marker of arterial stiffness, was assessed by applanation tonometry (SphygmoCor®). LS7 summary score (range 2-13) of 2-4 indicate ‘poor’, 5-9 ‘intermediate’, and 10-13 ‘ideal’ CVH. Cross-sectional analysis between the LS7 CVH 3-level categorical variable, cfPWV, and effect modification by race were examined. Multivariable linear regression models were conducted to examine the association between LS7 CVH and cfPWV, adjusting for model 1:(race, age); model 2:(model 1+ education, income). Results: Mean age 51±10.2 years. Compared to ‘ideal’ CVH, ‘poor’ ( β =1.08 m/s; 95% CI, 0.44, 1.71) and ‘intermediate’ ( β = 0.32 m/s; 95% CI, 0.20, 0.45) CVH groups had higher mean cfPWV in the minimal and fully adjusted models. Interaction of LS7 CVH and race on cfPWV was significant (p=.03) with Black women having higher mean cfPWV for each CVH group compared to White women. In race-stratified models, Black women with ‘poor’ ( β =1.56 m/s; 95% CI, 0.79, 2.32) and ‘intermediate’ ( β =0.46 m/s; 95% CI, 0.23, 0.68) CVH had higher cfPWV after minimal and full adjustment. Conclusions: Better CVH was associated with lower arterial stiffness. Compared to White women, Black women had greater arterial stiffness that was most pronounced for ‘poor’ and ‘intermediate’ CVH. Given that arterial stiffness is a prognostic measure, further study of health behaviors and psychosocial factors that contribute to higher arterial stiffness in Black women is warranted.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    URL: Article
    DOI: 10.1161/circ.146.suppl_1.15533
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2022
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  • 7
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    Abstract 2849: Family Variables in Early Recovery Predict Stroke Survivor Quality of Life in 12 months
    Ovid Technologies (Wolters Kluwer Health) ; 2007
    In:  Circulation Vol. 116, No. suppl_16 ( 2007-10-16)
    Details
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 116, No. suppl_16 ( 2007-10-16)
    Abstract: Purpose : Quality of life (QOL) after stroke may be influenced by the family context in addition to the stroke survivor’s physical ability. The purpose of this study was to determine whether baseline caregiver (CG) and family characteristics (age, physical function, depressive symptoms, and family communication) predict stroke survivor (SS) QOL: physical function, memory/thinking, social activities, communication, and mood at 1 year follow-up. Methods : Data were collected on 132 SS-CG dyads. SSs were 3–9 months post stroke, 30 to 83 years old ( M = 62.2 ± 12.6), male (64%), Caucasian (74 %), and had an ischemic stroke (88%). CGs were age 25 to 85 years ( M = 56.7 ± 13.7), female (74 %), well-educated (73 %), and spouses (80 %) enrolled in a multi-site caregiving study complementary to a clinical trial testing constraint-induced movement therapy in SSs. Measures included CG physical function (SF-36), CG depressive symptoms (CES-D), family communication (McMaster Family Assessment Device), and SS QOL (Stroke Impact Scale). Pearson’s correlations and hierarchal multiple regression analyses (n = 107) controlling for SS gender, the EXCITE intervention group, and SS functional level were used for analysis. Results : Baseline CG depressive symptoms were negatively related to both SS mood ( r = -.24, p 〈 .01) and social activities ( r = -.26, p = .01) at 1 year. Better family communication was related to higher SS memory/thinking ( r = -.24, p = .01). CG age and physical function were not associated with any SS QOL domains. In the regression models, CGs with more depressive symptoms (β = -.28, p = .007) at baseline predicted poorer SS mood ( F = 2.56, p = .02; R 2 = .13) and worse social participation (β = -.27, p = .01; F = 1.61, p = .15; R 2 = .09). Although the overall model was not significant ( F = 1.20, p = .31; R 2 = .07), worse family communication (β = -.22; p = .04) predicted poorer SS memory and thinking at 1 year. No CG or family characteristics were associated with SS physical or communication QOL domains. Conclusions : Early recognition and intervention of CG depressive symptoms may have profound effects on both CG and aspects of SS QOL in the early and chronic stroke recovery periods. Family interventions focusing on improving communication early may also improve long term stroke recovery.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    URL: Article
    DOI: 10.1161/circ.116.suppl_16.II_634
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2007
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  • 8
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    Abstract 11187: Perceptions of Patient Heart Failure Severity and Caregiver Inflammatory Markers: Interactions with Race and Education
    Ovid Technologies (Wolters Kluwer Health) ; 2021
    In:  Circulation Vol. 144, No. Suppl_1 ( 2021-11-16)
    Details
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 144, No. Suppl_1 ( 2021-11-16)
    Abstract: Background: Heart failure (HF) caregivers (CGs) may experience stress due to unpredictable patient disease trajectory. Interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) are reported to be elevated in dementia CGs, but less is known about HF CGs response to stress or relationships with social determinants of health such as education and race. Objective: To determine if social factors (race, education) modify the relationship between patient disease severity trajectory (NYHA class) and CG stress as measured by inflammatory biomarkers of IL-6 and hs-CRP among HF CGs. Methods: A secondary analysis was conducted using baseline data from Caregiver Opportunities for Optimizing Lifestyle (COOL) trial. Education was dichotomized into technical/high school or less versus college or post-graduate degree. Race was dichotomized as African American (AA) or White/Asian due to the low number of Asian CGs. Two-way analysis of variance tests were conducted for IL-6 and hs-CRP to test interaction effects between CG perceived NYHA class and education or race. Results: Participants (n=127) were predominantly female (n=117, 92.1%), AA (n=74, 58.3 %), and the majority (70.1%) reported a college or post-graduate education. Perceived NYHA class were reported as: I (n=32, 25.6%), II (n=31, 24.8%), III (n= 47, 37.6%), and IV (n=15, 12.0%). For hs-CRP, there was a significant interaction between race and NYHA class (p=.013). Higher hs-CRP levels were noted in class II, compared to class I or class III for AA CGs (p=.004). White/Asian CGs did not have significant hs-CRP differences between NYHA classes (p=.634). While similar trends were observed for IL-6 between race and NYHA class, it did not reach statistical significance. In the model for education and perceived disease severity, NYHA class was significant (p=.038) for hs-CRP. In the post hoc test for NYHA class, hs-CRP was highest among NYHA class II (p 〈 .02) for lower education levels. For IL-6, NYHA class was significant (p=.047); but the interaction effect with education was not significant (p=.687). Conclusions: Our findings suggest that CGs of AA race and/or lower education may experience higher stress earlier in the HF disease trajectory and may therefore benefit from targeted CG support interventions.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    URL: Article
    DOI: 10.1161/circ.144.suppl_1.11187
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2021
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  • 9
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    Abstract 4606: Appetite Ratings on Single-item Visual Analog Scale Identify Patients with Heart Failure at Risk for Malnutrition
    Ovid Technologies (Wolters Kluwer Health) ; 2008
    In:  Circulation Vol. 118, No. suppl_18 ( 2008-10-28)
    Details
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 118, No. suppl_18 ( 2008-10-28)
    Abstract: Background : Patients with heart failure (HF) are at risk for malnutrition due to multiple factors. A simple, clinically feasible tool to identify risk for malnutrition is needed. Visual analog scales have been used in studies on appetite but it is unknown whether an appetite scale can be used to identify patients with HF at risk for malnutrition. Purpose : To determine whether differences in kcal and protein intake could be identified in patients with HF grouped by their appetite rating. Method : A total of 137 patients (63% male, 60 ± 12 years, 56% NYHA class III/IV, ejection fraction (39 ± 14%) were recruited from outpatient HF clinics in the Midwest and South. Patients provided detailed 4-day food diaries that were reviewed by a registered dietitian to verify serving sizes and preparation methods and to obtain missing information. Patients were also asked to rate their appetite over the 4 days of diet recording on a 10 mm visual analog with anchors of “no appetite” and “extremely good appetite” Diaries were analyzed by Nutrition Data Systems software. Three series of between-group comparisons of kcal and protein (total and referenced to kg body weight) were made by t-tests using 4 mm (below midpoint), 5 mm (mid-point), and 6 mm (above mid-point) cut-points. Results : Significant differences in kcal and protein intake were identified between groups using the 6 mm cut point. A total of 36% of the patients had low appetite ratings ( 〈 6mm). Patients with low appetite ratings consumed 20% fewer total kcals (1555 vs. 1936 kcal, p = .001) and 23% fewer kcal/kg (18 vs. 22 kcal, p = .005) than those with high ratings. The low appetite group also consumed 24% less protein than the high appetite group (62 g vs. 82 g, p = .001). The .71 g/kg protein intake of the low appetite group was below the recommended .8 g/kg protein intake for adults. In contrast, the .91 g/kg protein intake of the high appetite group was above the recommended level. Conclusion : Patients with lower appetite ratings had kcal and protein intakes below recommended levels while those with high appetite ratings had adequate intake. These results provide evidence that rating appetite on a visual analog scale may be a simple tool that could be used clinically to identify patients with HF at risk for malnutrition. This research has received full or partial funding support from the American Heart Association, AHA Great Rivers Affiliate (Delaware, Kentucky, Ohio, Pennsylvania & West Virginia).
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    URL: Article
    DOI: 10.1161/circ.118.suppl_18.S_920-a
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2008
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  • 10
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    Abstract P426: Association Between Neighborhood Characteristics, Personal Resilience, and Arterial Stiffness Among Blacks: Results From the Morehouse-Emory Cardiovascular (MECA) Center for Health Equity
    Ovid Technologies (Wolters Kluwer Health) ; 2019
    In:  Circulation Vol. 139, No. Suppl_1 ( 2019-03-05)
    Details
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 139, No. Suppl_1 ( 2019-03-05)
    Abstract: Introduction: Arterial stiffness is associated with cardiovascular (CV) risk factors and adverse cardiovascular events. While inter-racial differences in arterial stiffness have been reported, factors contributing to intra-racial differences within Blacks are less known. We examined whether neighborhood characteristics and personal resilience factors were associated with arterial stiffness among Blacks. Hypothesis: More desirable neighborhood characteristics and greater personal resilience are associated with reduced arterial stiffness. Methods: We examined 385 Black adults (age 53 ± 10, 40% male) without known CV disease living in Atlanta, GA. Arterial stiffness was measured as augmentation index (AIX) and pulse wave velocity (PWV) using applanation tonometry (Sphygmocor Inc). Perceived residential neighborhood characteristics in 7 domains: aesthetic quality, walking environment, safety, food access, social cohesion, activity with neighbors, and violence were determined. Personal resilience was also assessed using standard questionnaires on experience of discrimination, environmental mastery, purpose in life, optimism, resilient coping, and depressive symptoms. Multiple linear regression models were used to examine the differences of arterial stiffness between the highest and the lowest tertiles of neighborhood characteristics and personal resilience factors after adjustment for age, gender, systolic blood pressure, body mass index, household income, education, marital status, and employment status. Results: Higher composite scores of neighborhood characteristics were associated with lower AIX (β=-3.42, 95% CI [-6.42 to -0.41], P=0.026; highest vs lowest tertiles). Specifically, higher scores of safety (β=-4.26, 95% CI [-7.34 to -1.17] , P=0.007) and social cohesion (β=-4.62 [-7.64 to -1.61], P=0.003) were associated with lower AIX (highest vs lowest tertiles for both). For factors of personal resilience, higher scores in purpose in life (β=-4.89 [-7.88 to -1.90] , P=0.001) and resilient coping (β=-3.26 [-6.36 to -0.15], P=0.040) were significantly associated with lower AIX (highest vs lowest tertiles for both). There were no significant associations between PWV and scores of neighborhood characteristics or personal resilience factors. Conclusion: In a study examining the impact of neighborhood and markers of resilience on arterial stiffness in an exclusively Black cohort, we found that better neighborhood characteristics and personal resilience factors were associated with lower pulse wave reflections (AIX).
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    URL: Article
    DOI: 10.1161/circ.139.suppl_1.P426
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
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