In:
Molecular Microbiology, Wiley, Vol. 88, No. 4 ( 2013-05), p. 784-797
Abstract:
P seudomonas aeruginosa causes serious acute and chronic infections in humans. Major differences exist in disease pathogenesis, clinical treatment and outcomes between acute and chronic infections. P . aeruginosa acute infection characteristically involves the type III secretion systems ( T 3 SS ) while chronic infection is often associated with the formation of biofilms, a major cause of difficulties to eradicate chronic infections. The choice between acute and chronic infection or the switch between them by P . aeruginosa is controlled by regulatory pathways that control major virulence factors and genes associated with biofilm formation. In this study, we characterized a hybrid sensor kinase PA 1611 that controls the expression of genes associated with acute and chronic infections in P . aeruginosa PAO 1. Expression of PA 1611 completely repressed T 3 SS and swarming motility while it promoted biofilm formation. The protein PA 1611 regulates two small RNAs ( sRNAs ), rsmY and rsmZ which in turn control RsmA . Independent of phosphate relay, PA 1611 interacts directly with RetS in vivo . The positive effect of RetS on factors associated with acute infection could presumably be restrained by PA 1611 when chronic infection conditions are present. This RetS – PA 1611 interaction, together with the known RetS – GacS interaction, may control disease progression and the lifestyle choice of P . aeruginosa.
Type of Medium:
Online Resource
ISSN:
0950-382X
,
1365-2958
DOI:
10.1111/mmi.2013.88.issue-4
Language:
English
Publisher:
Wiley
Publication Date:
2013
detail.hit.zdb_id:
1501537-3
detail.hit.zdb_id:
619315-8
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