In:
International Journal of Cancer, Wiley, Vol. 142, No. 8 ( 2018-04-15), p. 1620-1626
Abstract:
What's new? Tumor evolution, in which selection favors the survival of genetically and phenotypically distinct subclones, is a key feature of cancer progression. Within a single patient, such subclones may be shared across multiple tumors and carry somatic mutations that facilitate cancerous driver events. Here, an adapted two‐stage approach to mutation calling was used to identify shared somatic mutations across multiple matched tumors from the same patient. The approach showed high sensitivity in the detection of shared genetic variants in analyses of paired primary and recurrent glioblastoma samples, suggesting that it could potentially improve the capture of biologically relevant somatic mutations.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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