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  • 1
    Online Resource
    Online Resource
    High-power, short-duration ablation in the coronary sinus: clinical cases and preliminary observations on swine hearts
    Springer Science and Business Media LLC ; 2022
    In:  Journal of Interventional Cardiac Electrophysiology Vol. 63, No. 2 ( 2022-03), p. 311-321
    Details
    In: Journal of Interventional Cardiac Electrophysiology, Springer Science and Business Media LLC, Vol. 63, No. 2 ( 2022-03), p. 311-321
    Abstract: Coronary sinus-related arrhythmias are common; however, it is difficult to perform radiofrequency (RF) ablation at these sites efficiently and safely. High-power, short-duration ablation (HPSD) is a proven alternative strategy for pulmonary vein isolation (PVI); whether it can be applied to ablation of the coronary sinus is unknown. The purpose of this preliminary study was to evaluate the feasibility and safety of HPSD ablation in the coronary sinus. Methods Firstly, we demonstrated 4 clinical cases of 3 types of arrhythmias who had unsuccessful ablation with standard power initially, but received successful ablations with HPSD. Secondly, RF ablation was performed in the coronary sinus ostium (CSO) and middle cardiac vein (MCV) of 4 in vitro swine hearts. Two protocols were compared: HPSD (45 W/5 S×5 rounds) and a conventional strategy that used low-power, long-duration ablation (LPLD: 25 W/10 S ×5 rounds). The total duration of HPSD protocol was 25 s, and which of LPLD was 50 s. Results A total of 28 lesions were created. HPSD can produce longer, wider, deeper, and larger lesions than LPLD. This difference was more pronounced when the ablation was in the MCV. One instance of steam pop occurred during LPLD in the MCV. Conclusions HPSD is an effective alternative strategy for ablation in coronary sinus according to clinical applications and preliminary animal study. However, the safety needs to be further evaluated based on more animal and clinical studies.
    Type of Medium: Online Resource
    ISSN: 1383-875X , 1572-8595
    URL: Article
    DOI: 10.1007/s10840-021-00994-0
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2006887-6
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  • 2
    Online Resource
    Online Resource
    High efficiency and workflow of His bundle pacing and atrioventricular node ablation guided by three‐dimensional mapping system
    Wiley ; 2020
    In:  Pacing and Clinical Electrophysiology Vol. 43, No. 10 ( 2020-10), p. 1165-1172
    Details
    In: Pacing and Clinical Electrophysiology, Wiley, Vol. 43, No. 10 ( 2020-10), p. 1165-1172
    Abstract: Atrioventricular node (AVN) ablation combined with His bundle pacing is an effective strategy for permanent atrial fibrillation (AF) with rapid ventricular rate refractory to pharmacological therapy. We aimed to access the feasibility and efficiency of His bundle pacing and AVN ablation guided by three‐dimensional (3‐D) mapping system throughout the procedure. Methods Eighteen patients with permanent AF with refractory rate and symptoms were referred for His bundle pacing and AVN ablation guided by 3‐D mapping (CARTO3). Electroanatomic 3‐D mapping of the right atrium and right ventricle was performed by the ablation catheter with CARTO 3 system, followed by the visualization of the leads for implantation and AVN ablation. Results Implantation of His bundle and ventricular leads and AVN ablation were achieved successfully with the help of 3‐D mapping in 17 patients. Selective His bundle pacing was achieved in five patients (29.4%), and the other (70.6%) were nonselective His bundle pacing. The mean procedure duration was 99.4 ± 16.4 minutes. The mean fluoroscopy time was 7.0 ± 2.6 minutes. The time spent on His lead implantation was 6.1 ± 3.2 minutes. One patient experienced AVN ablation from left side under aortic valves due to no effect of ablation in right atrium. Conclusion His bundle pacing and AVN ablation guided by throughout real‐time 3‐D mapping system are of high‐efficiency and feasibility.
    Type of Medium: Online Resource
    ISSN: 0147-8389 , 1540-8159
    URL: Issue
    URL: Article
    DOI: 10.1111/pace.v43.10
    DOI: 10.1111/pace.14061
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2037547-5
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  • 3
    Online Resource
    Online Resource
    Autopolyploidy‐driven range expansion of a temperate‐originated plant to pan‐tropic under global change
    Wiley ; 2021
    In:  Ecological Monographs Vol. 91, No. 2 ( 2021-05)
    Details
    In: Ecological Monographs, Wiley, Vol. 91, No. 2 ( 2021-05)
    Abstract: Angiosperms are believed to have emerged initially in the tropics and expanded their distribution range poleward through diverse mechanisms, for example polyploidization‐driven cold tolerance evolution. Reversed expansion from temperate to pan‐tropic climates through a polyploidization‐driven shift in heat tolerance remains largely unknown. Here, we found autopolyploidy in relation to the global expansion of Solidago canadensis from its temperate‐climate native range in North American to hot‐summer climate in an introduced range. Our cytogeographical study of 2,062 accessions from 471 locations worldwide demonstrates that ploidy levels correlate negatively with latitude and positively with average temperature. An isotherm‐dependent shift of the climate niches at the threshold of 20°–24°C between geo‐cytotypes can be attributed mainly to autopolyploidy‐driven differentiation of heat tolerance; only polyploids and not diploids are able to complete sexual reproduction, germinate, and grow in the hot‐summer climate of low latitudes. Ploidy‐dependent fertility appears to play a key role in the hot‐summer introduced range in the northern hemisphere through both pre‐adaptation and rapid post‐introduction adaptive evolution of delayed flowering and improved heat tolerance during embryo development. The MaxEnt model predicts continued expansion of this plant species under global change. These results provide new insights into the mechanisms governing autopolyploidy‐driven backward range expansion of plant species from temperate origins.
    Type of Medium: Online Resource
    ISSN: 0012-9615 , 1557-7015
    URL: Issue
    URL: Article
    DOI: 10.1002/ecm.v91.2
    DOI: 10.1002/ecm.1445
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2010129-6
    SSG: 12
    SSG: 14
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  • 4
    Online Resource
    Online Resource
    Table1.docx
    Frontiers Media SA ; 2023
    In:  Frontiers in Cardiovascular Medicine Vol. 10 ( 2023-5-22)
    Details
    In: Frontiers in Cardiovascular Medicine, Frontiers Media SA, Vol. 10 ( 2023-5-22)
    Abstract: The purpose of this study was to evaluate the feasibility and outcomes of conduction system pacing (CSP) in patients with heart failure (HF) who had a severely reduced left ventricular ejection fraction (LVEF) of less than 30% (HFsrEF). Methods Between January 2018 and December 2020, all consecutive HF patients with LVEF  & lt; 30% who underwent CSP at our center were evaluated. Clinical outcomes and echocardiographic data [LVEF and left ventricular end-systolic volume (LVESV)], and complications were all recorded. In addition, clinical and echocardiographic (≥5% improvement in LVEF or ≥15% decrease in LVESV) responses were assessed. The patients were classified into a complete left bundle branch block (CLBBB) morphology group and a non-CLBBB morphology group according to the baseline QRS configuration. Results Seventy patients (66 ± 8.84 years; 55.7% male) with a mean LVEF of 23.2 ± 3.23%, LVEDd of 67.33 ± 7.47 mm and LVESV of 212.08 ± 39.74 ml were included. QRS configuration at baseline was CLBBB in 67.1% (47/70) of patients and non-CLBBB in 32.9%. At implantation, the CSP threshold was 0.6 ± 0.3 V @ 0.4 ms and remained stable during a mean follow-up of 23.43 ± 11.44 months. CSP resulted in significant LVEF improvement from 23.2 ± 3.23% to 34.93 ± 10.34% ( P   & lt; 0.001) and significant QRS narrowing from 154.99 ± 34.42 to 130.81 ± 25.18 ms ( P   & lt; 0.001). Clinical and echocardiographic responses were observed in 91.4% (64/70) and 77.1% (54/70) of patients. Super-response to CSP (≥15% improvement in LVEF or ≥30% decrease in LVESV) was observed in 52.9% (37/70) of patients. One patient died due to acute HF and following severe metabolic disorders. Baseline BNP (odds ratio: 0.969; 95% confidence interval: 0.939–0.989; P  = 0.045) was associated with echocardiographic response. The proportions of clinical and echocardiographic responses in the CLBBB group were higher than those in the non-CLBBB group but without significant statistical differences. Conclusions CSP is feasible and safe in patients with HFsrEF. CSP is associated with a significant improvement in clinical and echocardiographic outcomes, even for patients with non-CLBBB widened QRS.
    Type of Medium: Online Resource
    ISSN: 2297-055X
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fcvm.2023.1187169
    DOI: 10.3389/fcvm.2023.1187169.s001
    DOI: 10.3389/fcvm.2023.1187169.s002
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2781496-8
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