In:
Scientific Reports, Springer Science and Business Media LLC, Vol. 7, No. 1 ( 2017-11-16)
Abstract:
Accumulating evidence suggests a key role of the gut–microbiota–brain axis in the antidepressant actions of certain compounds. Ketamine, an N -methyl-D-aspartate receptor (NMDAR) antagonist, showed rapid and sustained antidepressant effects in treatment-resistant depressed patients. In contrast, another NMDAR antagonist, lanicemine, did not exhibit antidepressant effects in such patients. ( R )-ketamine, the ( R )-enantiomer of ketamine, has rapid-acting and long-lasting antidepressant effects in rodent models of depression. Here we compared the effects of ( R )-ketamine and lanicemine on depression-like phenotype and the composition of the gut microbiota in susceptible mice after chronic social defeat stress (CSDS). In behavioral tests, ( R )-ketamine showed antidepressant effects in the susceptible mice, whereas lanicemine did not. The 16S ribosomal RNA gene sequencing of feces demonstrated that ( R )-ketamine, but not lanicemine, significantly attenuated the altered levels of Bacteroidales , Clostridiales and Ruminococcaceae in the susceptible mice after CSDS. At the genus level, ( R )-ketamine significantly attenuated the marked increase of Clostridium in the susceptible mice. In contrast, the effects of lanicemine were less potent than those of ( R )-ketamine. This study suggests that the antidepressant effects of ( R )-ketamine might be partly mediated by the restoration of altered compositions of the gut microbiota in a CSDS model.
Type of Medium:
Online Resource
ISSN:
2045-2322
DOI:
10.1038/s41598-017-16060-7
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2017
detail.hit.zdb_id:
2615211-3
Permalink
