In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 5 ( 2021-5-20), p. e0251423-
Abstract:
Relative to European Americans, African Americans have lower 25-hydroxyvitamin D (25OHD) and vitamin D binding protein (VDBP) concentrations, higher 1,25-dihydroxyvitamin D (1,25(OH) 2 D 3 ) concentrations and bone mineral density (BMD), and paradoxically reduced burdens of calcified atherosclerotic plaque (subclinical atherosclerosis). To identify genetic factors contributing to vitamin D and BMD measures, association analysis of 〉 14M variants was conducted in a maximum of 697 African American-Diabetes Heart Study participants with type 2 diabetes (T2D). The most significant association signals were detected for VDBP on chromosome 4; variants rs7041 (β = 0.44, SE = 0.019, P = 9.4x10 -86 ) and rs4588 (β = 0.17, SE = 0.021, P = 3.5x10 -08 ) in the group-specific component (vitamin D binding protein) gene ( GC ). These variants were found to be independently associated. In addition, rs7041 was also associated with bioavailable vitamin D (BAVD; β = 0.16, SE = 0.02, P = 3.3x10 -19 ). Six rare variants were significantly associated with 25OHD, including a non-synonymous variant in HSPG2 (rs116788687; β = -1.07, SE = 0.17, P = 2.2x10 -10 ) and an intronic variant in TNIK (rs143555701; β = -1.01, SE = 0.18, P = 9.0x10 -10 ), both biologically related to bone development. Variants associated with 25OHD failed to replicate in African Americans from the Insulin Resistance Atherosclerosis Family Study (IRASFS). Evaluation of vitamin D metabolism and bone mineral density phenotypes in an African American population enriched for T2D could provide insight into ethnic specific differences in vitamin D metabolism and bone mineral density.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0251423
DOI:
10.1371/journal.pone.0251423.g001
DOI:
10.1371/journal.pone.0251423.g002
DOI:
10.1371/journal.pone.0251423.t001
DOI:
10.1371/journal.pone.0251423.t002
DOI:
10.1371/journal.pone.0251423.s001
DOI:
10.1371/journal.pone.0251423.s002
DOI:
10.1371/journal.pone.0251423.s003
DOI:
10.1371/journal.pone.0251423.s004
DOI:
10.1371/journal.pone.0251423.s005
DOI:
10.1371/journal.pone.0251423.s006
DOI:
10.1371/journal.pone.0251423.s007
DOI:
10.1371/journal.pone.0251423.s008
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3
Permalink