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  • 1
    Online Resource
    Online Resource
    Fear of cancer recurrence and disease progression in long‐term prostate cancer survivors after radical prostatectomy: A longitudinal study
    Wiley ; 2021
    In:  Cancer Vol. 127, No. 22 ( 2021-11-15), p. 4287-4295
    Details
    In: Cancer, Wiley, Vol. 127, No. 22 ( 2021-11-15), p. 4287-4295
    Abstract: Fear of cancer recurrence remains a burden to certain prostate cancer survivors even many years after their diagnosis and treatment. Health care professionals should monitor for fear of cancer recurrence to identify patients at risk and provide appropriate psychosocial care.
    Type of Medium: Online Resource
    ISSN: 0008-543X , 1097-0142
    URL: Issue
    URL: Article
    DOI: 10.1002/cncr.v127.22
    DOI: 10.1002/cncr.33836
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1479932-7
    detail.hit.zdb_id: 2599218-1
    detail.hit.zdb_id: 2594979-2
    detail.hit.zdb_id: 1429-1
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  • 2
    Online Resource
    Online Resource
    Diversity of cancer-related identities in long-term prostate cancer survivors after radical prostatectomy
    Springer Science and Business Media LLC ; 2021
    In:  BMC Cancer Vol. 21, No. 1 ( 2021-12)
    Details
    In: BMC Cancer, Springer Science and Business Media LLC, Vol. 21, No. 1 ( 2021-12)
    Abstract: Individuals affected by cancer need to integrate this experience into their personal biography as their life continues after primary therapy, leading to substantial changes in self-perception. This study identified factors uniquely associated with 5 different cancer-related identities in order to improve the understanding of how self-perception in men affected by prostate cancer is associated with certain clinical and psychosocial characteristics. Methods In this cross-sectional study, long-term prostate cancer survivors after radical prostatectomy were asked to choose one of 5 cancer-related identities that described them best. Associations with sociodemographic, clinical, and psychological variables were investigated using multivariable logistic regression. Results Three thousand three hundred forty-seven men (mean age 78.1 years) surveyed on average 15.6 years after prostatectomy were included. Most men favored the terms “someone who has had cancer” (43.9%) which was associated with a mild disease course, and “patient” (26.3%) which was associated with ongoing therapy and biochemical disease recurrence. The self-descriptions “cancer survivor” (16.8%), “cancer conqueror” (10.9%) and “victim” (2.1%) were less common. “Cancer survivor” was associated with high perceived disease severity (OR: 1.86 [1.44–2.40]). “Cancer survivor” and “cancer conqueror” were related to high benefit finding (OR: 1.89 [1.48–2.40] , OR: 1.46 [1.12–1.89] respectively), and only “cancer conqueror” was associated with high well-being (OR: 1.84 [1.35–2.50] ). Identification as “victim” was associated with a positive depression screening and low well-being (OR: 2.22 [1.15–4.31], OR: 0.38 [0.20–0.72] respectively) (all p   〈  0.05). Conclusions Although long-term survival is common among men affected by PCa, they display a large diversity in cancer-related identities, which are associated with unique clinical and psychological characteristics. These cancer-related identities and their distinctive properties are associated with psychological well-being even after a long follow-up.
    Type of Medium: Online Resource
    ISSN: 1471-2407
    URL: Article
    DOI: 10.1186/s12885-021-08776-7
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2041352-X
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  • 3
    Online Resource
    Online Resource
    Prostate cancer‐related anxiety among long‐term survivors after radical prostatectomy: A longitudinal study
    Wiley ; 2023
    In:  Cancer Medicine Vol. 12, No. 4 ( 2023-02), p. 4842-4851
    Details
    In: Cancer Medicine, Wiley, Vol. 12, No. 4 ( 2023-02), p. 4842-4851
    Abstract: Prostate cancer (PC)‐related anxiety is associated with clinically significant declines in health‐related quality of life (HRQoL) and psychological well‐being. This longitudinal study investigates course and predictors of PC‐related anxiety in long‐term PC survivors treated by radical prostatectomy (RP). Methods Two thousand nine hundred and three survivors from the multicenter German Familial PC Database completed the Memorial Anxiety Scale for PC on average 11 years after RP at the initial assessment in 2015 and then 5 years later. Hierarchical multiple linear regression was used to assess predictors of PC‐related anxiety at follow‐up. Results PC‐related anxiety remained stable over the 5 years. In hierarchical multiple linear regression, longitudinal predictors of PC‐related anxiety 5 years later included a lower level of education (beta: −0.035, p  = 0.019), biochemical recurrence (BCR; beta: 0.054, p  = 0.002), late BCR (beta: 0.054, p   〈  0.001), PC anxiety at initial assessment (beta: 0.556, p   〈  0.001), HRQoL (beta: −0.076, p   〈  0.001), depression and anxiety symptoms (beta: 0.072, p  = 0.001; beta: 0.165, p   〈  0.001). Predictors of prostate‐specific antigen (PSA) anxiety 5 years later included late BCR (beta: 0.044, p  = 0.019), PSA anxiety at initial assessment (beta: 0.339, p   〈  0.001), depression and anxiety symptoms (beta: 0.074, p  = 0.008; beta: 0.191, p   〈  0.001), and treatment decision regret (beta: 0.052, p  = 0.006). Conclusion PC‐related anxiety remains a burden to survivors many years after diagnosis and treatment. The respective disease‐specific anxiety was the strongest predictor of this anxiety 5 years later, which emphasizes the need of screening and monitoring in a timely manner for PC‐related anxiety. Treating urologists should screen, identify, and monitor patients at risk for targeted referrals to psychosocial services.
    Type of Medium: Online Resource
    ISSN: 2045-7634 , 2045-7634
    URL: Issue
    URL: Article
    DOI: 10.1002/cam4.v12.4
    DOI: 10.1002/cam4.5304
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2659751-2
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  • 4
    Online Resource
    Online Resource
    Prevalence, lifestyle, and risk factors of erectile dysfunction, premature ejaculation, and low libido in middle‐aged men: first results of the Bavarian Men's Health‐Study
    Wiley ; 2023
    In:  Andrology
    Details
    In: Andrology, Wiley
    Abstract: Erectile dysfunction (ED), premature ejaculation (PE), and low libido (LL) are reported as the most common male sexual dysfunctions. Objective To evaluate the prevalence of ED, PE, and LL and associations with lifestyle risk factors and comorbidities in middle‐aged men. Materials and methods This study included a population‐based random sample of 2500 50‐year‐old men who completed validated questionnaires, including the International Index of Erectile Function, the Erection Hardness Score, the Sexual Complaints Screener, and further questionnaires. Multiple logistic regression of outcomes ED, PE, and LL was used to model the association with explanatory factors. Results The prevalence of at least one sexual dysfunction was 30%. 21%, 5.2%, and 7.2% of men had ED, PE, and LL, respectively. The risk of ED increased with PE (odds ratio [OR]: 1.94, 95% confidence interval [95%CI] : 1.22–3.08), LL (OR: 2.04, 95%CI: 1.26–3.29), higher waist circumference (OR: 2.23, 95%CI: 1.67–2.96), and lower urinary tract symptoms (LUTS) (OR: 1.88, 95%CI: 1.39–2.55), partnership was associated with a lower risk (OR: 0.57, 95%CI: 0.39–0.85). The risk of PE increased with ED (OR: 1.94, 95%CI: 1.23–3.07), partnership (OR:5.42, 95%CI: 1.30–22.60), depression (OR: 2.37, 95%CI: 1.09–5.14), and LUTS (OR: 2.42, 95%CI: 1.52–3.87), and decreased with physical activity (OR: 0.44, 95%CI: 0.21–0.93). The risk of LL increased with ED (OR: 2.09, 95%CI: 1.31–3.34) and poorer self‐rated health (OR: 2.97, 95%CI: 1.54–5.71). Discussion and conclusions Roughly one in three 50‐year‐old men experience some form of sexual dysfunction and risk factors identified in this study underline the multifactorial nature of ED, PE, and LL. Many risk factors are modifiable which underlines the role of patient education. Modifiable risk factors should be addressed in patient education and men should take active measures to remove the risk posed by these factors.
    Type of Medium: Online Resource
    ISSN: 2047-2919 , 2047-2927
    URL: Article
    DOI: 10.1111/andr.13524
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2693844-3
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  • 5
    Online Resource
    Online Resource
    Treatment decision regret in long‐term survivors after radical prostatectomy: a longitudinal study
    Wiley ; 2023
    In:  BJU International Vol. 131, No. 5 ( 2023-05), p. 623-630
    Details
    In: BJU International, Wiley, Vol. 131, No. 5 ( 2023-05), p. 623-630
    Abstract: To investigate prevalence, course, and predictors of longitudinal decision regret in long‐term prostate cancer (PCa) survivors treated by radical prostatectomy (RP). Patients and Methods A total of 1003 PCa survivors from the multicentre German Familial PCa Database completed questionnaires on average 7 years after RP in 2007 and at follow‐up 13 years later in 2020. Patients completed standardised patient‐reported outcome measures on decision regret, decision‐making, health‐related quality of life, and psychosocial factors. Hierarchical multivariable logistic regression was used to assess predictors of longitudinal decision regret. Results Decision regret increased significantly over time (9.0% after 6.9 years in 2007 and 12% after 19 years in 2020; P  = 0.009). Favourable localised PCa (odds ratio [OR] 1.97, 95% confidence interval [CI] 1.05–3.68), decision regret in 2007 (OR 6.38, 95% CI 3.55–11.47), and a higher depression score (OR 1.37, 95% CI 1.03–1.83) were associated with decision regret in 2020. Shared decision‐making (OR 0.55, 95% CI 0.33–0.93) was associated with less decision regret. Conclusion The findings of the present study underline the perseverance of decision regret in long‐term PCa survivors and the definitive need for involving patients in the decision‐making process to mitigate regret over the long term.
    Type of Medium: Online Resource
    ISSN: 1464-4096 , 1464-410X
    URL: Issue
    URL: Article
    DOI: 10.1111/bju.v131.5
    DOI: 10.1111/bju.15955
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2019983-1
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  • 6
    Online Resource
    Online Resource
    Prevalence and determinants of decision regret in long-term prostate cancer survivors following radical prostatectomy
    Springer Science and Business Media LLC ; 2023
    In:  BMC Urology Vol. 23, No. 1 ( 2023-08-23)
    Details
    In: BMC Urology, Springer Science and Business Media LLC, Vol. 23, No. 1 ( 2023-08-23)
    Abstract: Patients with localized prostate cancer (PC) are faced with a wide spectrum of therapeutic options at initial diagnosis. Following radical prostatectomy (RP), PC patients may experience regret regarding their initial choice of treatment, especially when oncological and functional outcomes are poor. Impacts of psychosocial factors on decision regret, especially after long-term follow-up, are not well understood. This study aimed to investigate the prevalence and determinants of decision regret in long-term PC survivors following RP. Methods 3408 PC survivors (mean age 78.8 years, SD = 6.5) from the multicenter German Familial PC Database returned questionnaires after an average of 16.5 (SD = 3.8) years following RP. The outcome of decision regret concerning the initial choice of RP was assessed with one item from the Decision Regret Scale. Health-related quality of life (HRQoL), PC-anxiety, PSA-anxiety, as well as anxiety and depressive symptoms were considered for independent association with decision regret via multivariable logistic regression. Results 10.9% (373/3408) of PC survivors reported decision regret. Organ-confined disease at RP (OR 1.39, 95%CI 1.02–1.91), biochemical recurrence (OR 1.34, 1.00-1.80), low HRQoL (OR 1.69,1.28–2.24), depressive symptoms (OR 2.32, 1.52–3.53), and prevalent PSA anxiety (OR 1.88,1.17–3.01) were significantly associated with increased risk of decision regret. Shared decision-making reduced the odds of decision regret by 40% (OR 0.59, 0.41–0.86). Conclusions PC survivors may experience decision regret even after 16 years following RP. Promoting shared decision-making in light of both established and novel, potentially less invasive treatments at initial diagnosis may help mitigate long-term regret. Awareness regarding patients showing depressive symptoms or PSA anxiety should be encouraged to identify patients at risk of decision regret in need of additional psychological support.
    Type of Medium: Online Resource
    ISSN: 1471-2490
    URL: Article
    DOI: 10.1186/s12894-023-01311-9
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2059857-9
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