In:
Journal of Oral Pathology & Medicine, Wiley, Vol. 48, No. 8 ( 2019-09), p. 696-704
Abstract:
Transforming growth factor‐β (TGF‐β) exerts its versatile function (oncogenic or tumor suppressive role) during the carcinogenesis in tumor microenvironment‐dependent manner. Considering the tumor heterogeneity, spatial and temporal distribution of TGF‐β in oral squamous cell carcinoma (OSCC) remained to be elucidated. Methods Formalin‐fixed, paraffin‐embedded sections derived from 73 patients with OSCC were immunostained, revealing expression patterns of TGF‐β, both at the regions of tumor center (TC) and invasive tumor front (ITF). Results The TGF‐β levels on tumor cells, fibroblast‐like cells (FLCs), and tumor‐infiltrating lymphocytes (TILs) were comparable and showed to be cell‐type‐independent manner. Although TC regions harbored less positive staining of TGF‐β than ITF in tumor cells (TGF‐β Tumor cell ) (89.0% vs 98.3%; P = 0.037), FLCs (TGF‐β FLC ) (86.3% vs 96.6%; P = 0.043), and TILs (TGF‐β TIL ) (83.6% vs 94.8%; P = 0.044), respectively, TGF‐β at TC regions, not at ITF, correlated to poor clinical outcomes. At TC regions, patients with high TGF‐β Tumor cell had high recurrence rate, and patients with high TGF‐β TIL showed inferior worst pattern of invasion. Of note, high TGF‐β Tumor cell at TC predicted shorter overall survival time, recurrence‐free survival, and disease‐free survival in patients with OSCC, whereas high TGF‐β TIL had no association with survival time. Cox regression analyses indicated that tumor cell‐derived TGF‐β at TC was an independent risk factor for survival outcome in patients with OSCC. Conclusions Tumor cell‐derived TGF‐β at TC regions, but not at ITF, could be a promising predictor for disease recurrence and poor prognosis of patients with OSCC.
Type of Medium:
Online Resource
ISSN:
0904-2512
,
1600-0714
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
2026385-5
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