In:
Brain Communications, Oxford University Press (OUP)
Abstract:
Juvenile myoclonic epilepsy is an idiopathic generalized epilepsy syndrome associated with photosensitivity in approximately 30-40% of cases. Microstates consist in brief period of times during which the topography of the whole resting-state EEG signal is characterized by a specific configuration. Previous neurophysiological and neuroimaging studies have suggested that microstate B may represent activity within the visual network. In this case-control study, we aimed to investigate whether anatomical and functional alterations in the visual network observed in individuals with PS could lead to changes in microstate B dynamics in photosensitive patients with juvenile myoclonic epilepsy. Resting-state EEG microstate analysis was performed on twenty-eight patients with juvenile myoclonic epilepsy. Of these, fifteen patients exhibited photosensitivity, while the remaining thirteen served as non-photosensitive controls. The two groups were carefully matched in terms of age, sex, seizure control, and anti-seizure medications. Multivariate ANOVA and repeated-measures ANOVA were performed to assess significant differences in microstates metrics and syntax between the photosensitive and the non-photosensitive group. Post-hoc false discovery rate adjusted unpaired t-tests were used to determine differences in specific microstates classes between the two groups. The four classical microstates (class A, B, C, D) accounted for 72.8% of the total EEG signal variance in the photosensitive group and 75.64% in the non-photosensitive group. Multivariate ANOVA revealed a statistically significant class*group interaction on microstates temporal metrics (p = 0.021). False discovery rate adjusted univariate ANOVAs indicated a significant class*group interaction for both mean occurrence (p = 0.002) and coverage (p = 0.03), but not for mean duration (p = 0.14). Post-hoc, false discovery rate adjusted unpaired T-tests showed significantly higher coverage (p = 0.02) and occurrence (p = 0.04) of microstate class B in photosensitive patients compared with non-photosensitive participants, along with an increased probability of transitioning from microstates C (p = 0.04) and D (p = 0.02) to microstate B. No significant differences were found concerning the other microstate classes between the two groups. Our study provides novel insights on resting-state EEG microstates dynamics underlying photosensitivity in patients with juvenile myoclonic epilepsy. The increased representation of microstate B in these patients might reflect the resting state overactivation of the visual system underlying photosensitivity. Further research is warranted to investigate microstate dynamics in other photosensitive epilepsy syndromes.
Type of Medium:
Online Resource
ISSN:
2632-1297
DOI:
10.1093/braincomms/fcae054
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
2024
detail.hit.zdb_id:
3020013-1
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