In:
Radiochimica Acta, Walter de Gruyter GmbH, Vol. 89, No. 6 ( 2001-6-1), p. 413-417
Kurzfassung:
Some features of a novel 90 Sr- 90 Y generator which employs supported liquid membrane (SLM) to separate carrier-free 90 Y from 90 Sr present in the high level waste of the spent fuel of reactor are described. After ascertaining the purity of 90 Y particularly with respect to 90 Sr breakthrough, its complexation was studied with a few oxo/aza donor ligands, such as DTPA, EDTMP, DOTA, TETA and a cyclic phosphonate, CTMP. These studies were primarily carried out to adjudge the quality of the 90 Y obtained from a novel 90 Sr- 90 Y generator and ascertain its usability for labelling biomolecules such as antibodies and peptides. The DOTA complexes are most stable at 37 C in human serum; they appear to be ideal bifunctional chelating agent for use in radioimmunotherapy with 90 Y.
Materialart:
Online-Ressource
ISSN:
2193-3405
,
0033-8230
DOI:
10.1524/ract.2001.89.6.413
Sprache:
Englisch
Verlag:
Walter de Gruyter GmbH
Publikationsdatum:
2001
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