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  • 1
    Online Resource
    Online Resource
    Preterm Nutrition and Clinical Outcomes
    SAGE Publications ; 2020
    In:  Global Pediatric Health Vol. 7 ( 2020-01), p. 2333794X2093785-
    Details
    In: Global Pediatric Health, SAGE Publications, Vol. 7 ( 2020-01), p. 2333794X2093785-
    Abstract: Background. In low-income countries, preterm nutrition is often inadequately addressed. The aim of the study was to assess the patterns of feeding and associated clinical outcomes of preterm neonates admitted to neonatal intensive care units in Ethiopia. Method. This was a multicenter, prospective study. Infants’ clinical characteristics at birth, daily monitoring of feeding history, and weight measurements were collected. An outcome assessment was completed at 28 days. Result. For this analysis, 2560 infants (53% male) were eligible. The mean (SD) gestational age was 33.1 (2.2) weeks. During the hospital stay the proportion of infants on breast milk only, preterm formula, term formula, and mixed feeding was 58%, 27.4%, 1.6%, and 34.1%, respectively. Delay in enteral feeding was associated with increased risk of death (odds ratio [OR] = 1.92, 95% confidence interval [CI] = 1.33-2.78; P 〈 .001) and (OR = 5.06, 95% CI = 3.23-7.87; P 〈 .001) for 1 to 3 and 4 to 6 days of delay in enteral feeding, respectively, after adjusting for possible confounders. The length of delay in enteral feeding was associated with increased risk of hypoglycemia (OR = 1.2, 95% CI = 1.1-1.2; P = .005). The mortality rate was lower in hospitals providing preterm formula more often ( P = .04). Half of the infants continued losing weight at the time of discharge. Conclusion. Delayed enteral feeding significantly increases the risk of mortality before discharge and hypoglycemia in preterm infants in resource-limited settings. Ensuring adequate nutritional support of preterm infants is highly needed.
    Type of Medium: Online Resource
    ISSN: 2333-794X , 2333-794X
    URL: Article
    DOI: 10.1177/2333794X20937851
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2785531-4
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  • 2
    Online Resource
    Online Resource
    Antenatal Steroid Utilization in Ethiopia
    SAGE Publications ; 2021
    In:  Global Pediatric Health Vol. 8 ( 2021-01), p. 2333794X2199034-
    Details
    In: Global Pediatric Health, SAGE Publications, Vol. 8 ( 2021-01), p. 2333794X2199034-
    Abstract: Background. Administration of antenatal corticosteroids to pregnant mothers is one of the most effective interventions to decrease preterm neonatal mortality. In this study we assessed antenatal steroid utilization by the mother and its effect on preterm babies. Method. Two years prospective, multicenter, observational study was conducted in selected hospitals of Ethiopia. Significance of the study outcomes was tested by chi-square and binary logistic regression. Result. Out of 4919 participants, 1575 preterm babies whose gestational ages were below 35 weeks were included in the study. Use of antenatal dexamethasone was 37.5% among study participants. The risk of early onset neonatal sepsis 235 (40.4%) was higher in preterm babies whose mother took antenatal dexamethasone ( P-value .002) than those who did not. Conclusion. Antenatal dexamethasone use in our study was comparable with other low and middle-income countries. Risk of early onset neonatal sepsis was higher among infants whose mother took antenatal dexamethasone.
    Type of Medium: Online Resource
    ISSN: 2333-794X , 2333-794X
    URL: Article
    DOI: 10.1177/2333794X21990344
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2785531-4
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  • 3
    Online Resource
    Online Resource
    Hypothermia in Preterm Newborns: Impact on Survival
    SAGE Publications ; 2020
    In:  Global Pediatric Health Vol. 7 ( 2020-01), p. 2333794X2095765-
    Details
    In: Global Pediatric Health, SAGE Publications, Vol. 7 ( 2020-01), p. 2333794X2095765-
    Abstract: Background. Globally, prematurity is the leading cause of neonatal mortality, and hypothermia is one of its contributing factors. The goal of this study was to determine the association between hypothermia and mortality. Methods. A prospective, multi-center, descriptive clinical study was conducted in 5 hospitals in Ethiopia. Axillary temperatures were taken at the time of admission to the newborn intensive care units (NICU) and followed during the NICU stay. Results. A total of 3852 premature neonates ( 〈 37 weeks) were admitted to the NICUs from July 2016 to May 2018. Of these infants, 1109 (28.8%) died and 2991 (79.6%) had hypothermia. Hypothermia was associated with perinatal asphyxia (89.5%), RDS (86.2%), and resuscitation at birth (82.7%). Admission temperatures in preterm newborns were inversely associated with mortality and morbidity. Conclusion. Hypothermia at admission is associated with neonatal mortality in premature neonates in Ethiopia. RDS and perinatal asphyxia were the main factors associated with hypothermia. The very high prevalence and association with mortality warrants quality improvement interventions.
    Type of Medium: Online Resource
    ISSN: 2333-794X , 2333-794X
    URL: Article
    DOI: 10.1177/2333794X20957655
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2785531-4
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    Online Resource
  • 4
    Online Resource
    Online Resource
    Hyperbilirubinemia in Preterm Infants Admitted to Neonatal Intensive Care Units in Ethiopia
    SAGE Publications ; 2020
    In:  Global Pediatric Health Vol. 7 ( 2020-01), p. 2333794X2098580-
    Details
    In: Global Pediatric Health, SAGE Publications, Vol. 7 ( 2020-01), p. 2333794X2098580-
    Abstract: Background. Hyperbilirubinemia is prevalent and protracted in preterm infants. This study assessed the pattern of hyperbilirubinemia in preterm infants in Ethiopia. Methods. This study was part of multi-centered prospective, cross-sectional, observational study that determined causes of death among preterm infants. Jaundice was first identified based on clinical visual assessment. Venous blood was then sent for total and direct serum bilirubin level measurements. For this study, a total serum bilirubin level ≥5 mg/dL was taken as the cutoff point to diagnose hyperbilirubinemia. Based on the bilirubin level and clinical findings, the final diagnoses of hyperbilirubinemia and associated complications were made by the physician. Result. A total of 4919 preterm infants were enrolled into the overall study, and 3852 were admitted to one of the study’s newborn intensive care units. Of these, 1779 (46.2%) infants were diagnosed with hyperbilirubinemia. Ten of these (0.6%) developed acute bilirubin encephalopathy. The prevalence of hyperbilirubinemia was 66.7% among the infants who were less than 28 weeks of gestation who survived. Rh incompatibility ( P = .002), ABO incompatibility ( P = .0001), and sepsis ( P = .0001) were significantly associated with hyperbilirubinemia. Perinatal asphyxia ( P-value = 0.0001) was negatively associated with hyperbilirubinemia. Conclusion. The prevalence of hyperbilirubinemia in preterm babies admitted to neonatal care units in Ethiopia was high. The major risk factors associated with hyperbilirubinemia in preterm babies in this study were found to be ABO incompatibility, sepsis, and Rh isoimmunization.
    Type of Medium: Online Resource
    ISSN: 2333-794X , 2333-794X
    URL: Article
    DOI: 10.1177/2333794X20985809
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2785531-4
    Location Call Number Limitation Availability
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    Online Resource
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