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  • Wiley  (2)
  • De Keyser, Jacques  (2)
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  • Wiley  (2)
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  • 1
    Online Resource
    Online Resource
    Intra‐arterial blood pressure reading in intensive care unit patients in the lateral position
    Wiley ; 2012
    In:  Journal of Clinical Nursing Vol. 21, No. 13-14 ( 2012-07), p. 1825-1830
    Details
    In: Journal of Clinical Nursing, Wiley, Vol. 21, No. 13-14 ( 2012-07), p. 1825-1830
    Abstract: Background.  Routine lateral turning of patients has become an accepted standard of care to prevent complications of immobility. The haemodynamic and oxygenation effects for patients in both lateral positions (45°) are still a matter of debate. We aimed to study the effect of these positions on blood pressure, heart rate and oxygenation in a general intensive care population. Design.  Observational study. Method.  Twenty stable intensive care unit patients had intra‐arterial blood pressure recordings in the supine and lateral positions with the correction of hydrostatic height compared with a fixed reference point (phlebostatic level). A multilevel model was used to analyse the data. Results.  Mean arterial pressure readings in the lateral positions were, on average, 5 mmHg higher than in the supine position ( p   〈  0·001). There were no significant differences between mean arterial pressure recordings in the left and right lateral position ( p  = 1·0). No important differences in oxygenation and heart rate were observed. After correction for covariates, the effects persisted. Conclusion.  Our study demonstrated an increase, albeit small, in blood pressure in the lateral positions. No major differences between the left and right lateral position were found. No important differences in oxygenation and heart rate were observed. Relevance to clinical practice.  Turning haemodynamically stable patients in the intensive care unit has no important effects on blood pressure measurements when continuous hydrostatic height correction is applied.
    Type of Medium: Online Resource
    ISSN: 0962-1067 , 1365-2702
    URL: Issue
    URL: Article
    DOI: 10.1111/jcn.2012.21.issue-13-14
    DOI: 10.1111/j.1365-2702.2011.03840.x
    Language: English
    Publisher: Wiley
    Publication Date: 2012
    detail.hit.zdb_id: 1159483-4
    detail.hit.zdb_id: 2006661-2
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  • 2
    Online Resource
    Online Resource
    Therapeutic Potential of Fluoxetine in Neurological Disorders
    Wiley ; 2008
    In:  CNS Neuroscience & Therapeutics Vol. 14, No. 2 ( 2008-06), p. 153-164
    Details
    In: CNS Neuroscience & Therapeutics, Wiley, Vol. 14, No. 2 ( 2008-06), p. 153-164
    Abstract: The selective serotonin reuptake inhibitor (SSRI) fluoxetine, which is registered for a variety of psychiatric disorders, has been found to stimulate the cAMP‐responsive element binding protein (CREB), increase the production of brain‐derived neurotrophic factor (BNDF) and the neurotrophic peptide S100β, enhance glycogenolysis in astrocytes, block voltage‐gated calcium and sodium channels, and decrease the conductance of mitochondrial voltage‐dependent anion channels (VDACs). These mechanisms of actions suggest that fluoxetine may also have potential for the treatment of a number of neurological disorders. We performed a Pubmed search to review what is known about possible therapeutic effects of fluoxetine in animal models and patients with neurological disorders. Beneficial effects of fluoxetine have been noted in animal models of stroke, multiple sclerosis, and epilepsy. Fluoxetine was reported to improve neurological manifestations in patients with Alzheimer's disease, stroke, Huntington's disease, multiple sclerosis, traumatic brain injury, and epilepsy. Clinical studies so far were small and often poorly designed. Results were inconclusive and contradictory. However, the available preclinical data justify further clinical trials to determine the therapeutic potential of fluoxetine in neurological disorders.
    Type of Medium: Online Resource
    ISSN: 1755-5930 , 1755-5949
    URL: Issue
    URL: Article
    DOI: 10.1111/cns.2008.14.issue-2
    DOI: 10.1111/j.1527-3458.2008.00040.x
    Language: English
    Publisher: Wiley
    Publication Date: 2008
    detail.hit.zdb_id: 2423467-9
    detail.hit.zdb_id: 2423461-8
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