In:
European Journal of Organic Chemistry, Wiley, Vol. 2017, No. 42 ( 2017-11-16), p. 6265-6273
Abstract:
Azo‐directed rhodium(III)‐catalysed C–H functionalization and intramolecular annulation reactions between azobenzenes and internal olefins are described. This transformation leads to 2,3‐disubstituted free (NH)‐indoles with excellent site‐selectivity and functional‐group compatibility. The resulting indoles were evaluated for in‐vitro anticancer activity against human endometrial adenocarcinoma cells (Ishikawa), triple negative human breast cancer cells (MDA‐MB‐231), and human renal cancer cells (Caki‐1). 2,3‐Disubstituted indoles 3b , 3k , and 5b were found to show potent cytotoxic effects that were competitive with the anticancer agent doxorubicin.
Type of Medium:
Online Resource
ISSN:
1434-193X
,
1099-0690
DOI:
10.1002/ejoc.v2017.42
DOI:
10.1002/ejoc.201701001
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
1475010-7
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