In:
Journal of Child Neurology, SAGE Publications, Vol. 27, No. 4 ( 2012-04), p. 451-457
Abstract:
Data from the whole-body hypothermia trial was analyzed to examine the effects of phenobarbital administration prior to cooling (+PB) on the esophageal temperature ( T e ) profile, during the induction phase of hypothermia. A total of 98 infants were analyzed. At enrollment, +PB infants had a higher rate of severe hypoxic-ischemic encephalopathy and clinical seizures and lower T e and cord pH than infants that have not received phenobarbital (–PB). There was a significant effect of phenobarbital itself and an interaction between phenobarbital and time in the T e profile. Mean T e in the +PB group was lower than in the –PB group, and the differences decreased over time. In +PB infants, the time to surpass target T e of 33.5°C and to reach the minimum T e during overshoot were shorter. In conclusion, the administration of phenobarbital before cooling was associated with changes that may reflect a reduced thermogenic response associated with barbiturates.
Type of Medium:
Online Resource
ISSN:
0883-0738
,
1708-8283
DOI:
10.1177/0883073811419317
Language:
English
Publisher:
SAGE Publications
Publication Date:
2012
detail.hit.zdb_id:
2068710-2
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