In:
PLOS Neglected Tropical Diseases, Public Library of Science (PLoS), Vol. 15, No. 4 ( 2021-4-30), p. e0009037-
Abstract:
Severe fever with thrombocytopenia syndrome (SFTS) was listed as one of the most severe infectious disease by world health organization in 2017. It can mostly be transmitted by tick bite, while human-to-human transmission has occurred on multiple occasions. This study aimed to explore the epidemiological and clinical characteristics and make risk analysis of SFTS human-to-human transmission. Methods Descriptive and spatial methods were employed to illustrate the epidemiological and clinical characteristics of SFTS human-to-human transmission. The risk of SFTS human-to-human transmission was accessed through secondary attack rate (SAR) and basic reproductive number (R 0 ). Logistic regression analysis was used to identify the associated risk factors. Results A total of 27 clusters of SFTS human-to-human transmission were reported in China and South Korea during 1996–2019. It mainly occurred among elder people in May, June and October in central and eastern China. The secondary cases developed milder clinical manifestation and better outcome than the index cases. The incubation period was 10.0 days (IQR:8.0–12.0), SAR was 1.72%-55.00%, and the average R 0 to be 0.13 (95%CI:0.11–0.16). Being blood relatives of the index case, direct blood/bloody secretion contact and bloody droplet contact had more risk of infection (OR = 6.35(95%CI:3.26–12.37), 38.01 (95%CI,19.73–73.23), 2.27 (95%CI,1.01–5.19)). Conclusions SFTS human-to-human transmission in China and South Korea during 1996–2019 had obvious spatio-temporal distinction. Ongoing assessment of this transmission risk is crucial for public health authorities though it continues to be low now.
Type of Medium:
Online Resource
ISSN:
1935-2735
DOI:
10.1371/journal.pntd.0009037
DOI:
10.1371/journal.pntd.0009037.g001
DOI:
10.1371/journal.pntd.0009037.g002
DOI:
10.1371/journal.pntd.0009037.t001
DOI:
10.1371/journal.pntd.0009037.t002
DOI:
10.1371/journal.pntd.0009037.t003
DOI:
10.1371/journal.pntd.0009037.t004
DOI:
10.1371/journal.pntd.0009037.s001
DOI:
10.1371/journal.pntd.0009037.s002
DOI:
10.1371/journal.pntd.0009037.s003
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2429704-5
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