In:
Brazilian Journal of Development, South Florida Publishing LLC, Vol. 8, No. 2 ( 2022-02-22), p. 13981-14001
Abstract:
Obesity is a chronic condition related to multiple comorbidities such as hypertension, type 2 diabetes, periodontal and cardiovascular diseases. Obesity can lead to a metabolic change, creating a prolonged and low-intensity inflammatory process. This study aims to analyze the plasma and saliva proteomes of young adults with obesity and overweight comparing to normal weight individuals, to reveal if the rise on body mass influences the proteomic profiles. The reported population consisted of 18 students and/or employees of Rio de Janeiro State, Brazil, aged between 18 and 35 years. Individuals were categorized according to their anthropometric measures in the Normal Weight, Overweight and Obese groups. Proteomic characterization was assessed by quantitative Mass Spectrometry (LC-ESI Q/TOF). In addition, cytokines were identified by Multiplex analysis. A total of 118 human proteins from saliva and plasma were identified, including 7 that were common between both fluids. The salivary and plasma proteomes seemed to be related to the body mass index, once the three groups showed distinct proteome profiles. Altogether 49 proteins presented different abundances between the obese, overweight, and normal weight individuals. The main functional category modified in both fluids was the immune response. Most of the modified proteins were previously reported as related to inflammatory diseases, such as cardiovascular diseases and Type 2 Diabetes Mellitus, in particular alpha-1 antitrypsin, C3 complement, alpha-1-antichymotrypsin, zinc-alpha2-glycoprotein, apolipoprotein AI and lysozyme, that could be tested to possible use as early biomarkers of obesity comorbidities.
Type of Medium:
Online Resource
ISSN:
2525-8761
DOI:
10.34117/bjdv8n2-363
Language:
Unknown
Publisher:
South Florida Publishing LLC
Publication Date:
2022
detail.hit.zdb_id:
2873644-8
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