In:
Journal of Gastroenterology and Hepatology, Wiley, Vol. 37, No. 10 ( 2022-10), p. 1865-1872
Abstract:
Gastric IgG4‐related disease (IgG4‐RD) can mimic malignancy, submucosal tumors (SMT), and ulcers, leading to over‐triage and unnecessary medical interventions such as gastrectomy. The variability in the clinicopathological presentation of IgG4‐related disease is not yet well defined, posing a diagnostic challenge. Methods Following the PRISMA Extension for Scoping Reviews, we searched MEDLINE and EMBASE for all peer‐reviewed articles using keywords including “gastritis,” “stomach,” “gastrointestinal stromal tumor,” and “IgG4‐RD” from their inception to December 28, 2021. Results Thirty‐nine articles, including 2 observational studies and 42 cases, were included in the systematic review. While bottom‐heavy lymphoplasmacytic mucosal infiltration is a characteristic finding of gastric IgG4‐RD, it was only present in less than half of the patients in the observational studies. Patients with gastric IgG4‐RD were more likely to be diagnosed with gastrointestinal stromal tumor (GIST), gastric cancer, or peptic ulcer disease and their clinical course involved resection (51.3%) or even gastrectomy. Diagnosis of gastric IgG4‐RD was most frequently made by post‐operative pathological analysis. Conclusion This systematic review summarizes the current understanding of the characteristics of gastric IgG4‐RD. Increased awareness of gastric IgG4‐RD as a differential diagnosis of gastric SMT or ulcers among clinicians is crucial in order to reduce unnecessary high‐risk, invasive interventions.
Type of Medium:
Online Resource
ISSN:
0815-9319
,
1440-1746
Language:
English
Publisher:
Wiley
Publication Date:
2022
detail.hit.zdb_id:
2006782-3
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