In:
Acta Ophthalmologica, Wiley, Vol. 97, No. 1 ( 2019-02), p. 60-67
Kurzfassung:
To characterize the two‐dimensional parameter Bruch's membrane opening minimum rim area ( BMO ‐ MRA ) in spectral domain optical coherence tomography ( SD ‐ OCT ) of the optic nerve head ( ONH ) compared to minimum rim width ( BMO ‐ MRW ) and retinal nerve fibre layer ( RNFL ) thickness in a large patient cohort. Methods Case–control, cross‐sectional study of 705 eyes of 445 participants. A total of 449 eyes with glaucoma, 67 eyes with ocular hypertension and 189 healthy controls, underwent SD ‐ OCT and confocal laser scanning tomography ( CSLT ), visual field testing and clinical examination. Morphometric ONH parameters, visual field function and diagnostic power were compared. Main outcome measures were SD ‐ OCT ‐derived BMO ‐ MRA , BMO ‐ MRW , RNFL thickness and CSLT ‐derived rim area ( DM ‐ RA ). Results Mean ONH area was 2.11 ± 0.57 mm 2 ; mean BMO area was 1.89 ± 0.45 mm 2 . Correlation of mean deviation in visual field to morphometric parameters was ρ = 0.70, (p 〈 0.001) for RNFL thickness, ρ = 0.68 (p 〈 0.001) for BMO ‐ MRA , ρ = 0.66 (p 〈 0.001) for BMO ‐ MRW . These correlations were not significantly different (p 〉 0.05), while DM ‐ RA correlated significantly worse ( ρ = 0.55; p 〈 0.001). In receiver operating characteristics, the calculated area under the curve ( AUC ) and sensitivity at 90% specificity to differentiate glaucoma were 0.87% and 70.1% for BMO ‐ MRA , 0.86% and 68.1% for RNFL thickness, 0.84% and 66.0% for BMO ‐ MRW , 0.82% and 51.3% for DM ‐ RA . Conclusions In a heterogenous clinical cohort of glaucoma patients, all analysed SD ‐ OCT parameters excel DM ‐ RA of CSLT . The two‐dimensional parameter BMO ‐ MRA shows comparable levels of diagnostic power to detect glaucoma compared to established parameters BMO ‐ MRW and RNFL thickness. Given higher comparability between ONH sizes, BMO ‐ MRA might become an additional standard tool in SD ‐ OCT imaging for glaucoma.
Materialart:
Online-Ressource
ISSN:
1755-375X
,
1755-3768
DOI:
10.1111/aos.2019.97.issue-1
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2019
ZDB Id:
2466981-7
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