In:
Natural Product Communications, SAGE Publications, Vol. 17, No. 5 ( 2022-05), p. 1934578X2211053-
Abstract:
Using various column chromatographic methods, 5 triterpene tetraglycosides (1−5), including one new compound, namely holothurin A 6 (1), were obtained from the water soluble part of the methanol extract of the sea cucumber Stichopus herrmanni. Their structures were confirmed by careful analysis of the 1D and 2D NMR, and HR ESI QTOF mass spectra. Noteworthily, 24-dehydroechinoside A (3) showed potent cytotoxicity to 5 human cancer cell lines {HepG2 (hepatoma cancer), KB (epidermoid carcinoma), LNCaP (prostate cancer), MCF7 (breast cancer), and SK-Mel2 (melanoma)} with IC 50 values ranging from 0.19 ± 0.03 to 1.17 ± 0.18 µM.
Type of Medium:
Online Resource
ISSN:
1934-578X
,
1555-9475
DOI:
10.1177/1934578X221105369
Language:
English
Publisher:
SAGE Publications
Publication Date:
2022
detail.hit.zdb_id:
2430442-6
SSG:
15,3
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