In:
PLOS Neglected Tropical Diseases, Public Library of Science (PLoS), Vol. 17, No. 1 ( 2023-1-25), p. e0010802-
Abstract:
Plasmodium parasites caused 241 million cases of malaria and over 600,000 deaths in 2020. Both P . falciparum and P . ovale are endemic to Mali and cause clinical malaria, with P . falciparum infections typically being more severe. Here, we sequenced RNA from nine pediatric blood samples collected during infections with either P . falciparum or P . ovale , and characterized the host and parasite gene expression profiles. We found that human gene expression varies more between individuals than according to the parasite species causing the infection, while parasite gene expression profiles cluster by species. Additionally, we characterized DNA polymorphisms of the parasites directly from the RNA-seq reads and found comparable levels of genetic diversity in both species, despite dramatic differences in prevalence. Our results provide unique insights into host-pathogen interactions during malaria infections and their variations according to the infecting Plasmodium species, which will be critical to develop better elimination strategies against all human Plasmodium parasites.
Type of Medium:
Online Resource
ISSN:
1935-2735
DOI:
10.1371/journal.pntd.0010802
DOI:
10.1371/journal.pntd.0010802.g001
DOI:
10.1371/journal.pntd.0010802.g002
DOI:
10.1371/journal.pntd.0010802.g003
DOI:
10.1371/journal.pntd.0010802.t001
DOI:
10.1371/journal.pntd.0010802.s001
DOI:
10.1371/journal.pntd.0010802.s002
DOI:
10.1371/journal.pntd.0010802.s003
DOI:
10.1371/journal.pntd.0010802.s004
DOI:
10.1371/journal.pntd.0010802.s005
DOI:
10.1371/journal.pntd.0010802.s006
DOI:
10.1371/journal.pntd.0010802.s007
DOI:
10.1371/journal.pntd.0010802.s008
DOI:
10.1371/journal.pntd.0010802.s009
DOI:
10.1371/journal.pntd.0010802.s010
DOI:
10.1371/journal.pntd.0010802.s011
DOI:
10.1371/journal.pntd.0010802.r001
DOI:
10.1371/journal.pntd.0010802.r002
DOI:
10.1371/journal.pntd.0010802.r003
DOI:
10.1371/journal.pntd.0010802.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2429704-5
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