In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 8 ( 2022-8-19), p. e0273385-
Abstract:
We investigated the mechanisms by which chronic administration of a multideficient diet after weaning alters bodily Na + handling, and culminates in high systolic blood pressure (SBP) at a juvenile age. From 28 to 92 days of age, weaned male Wistar rats were given a diet with low content and poor-quality protein, and low lipid, without vitamin supplementation, which mimics the diets consumed in impoverished regions worldwide. We measured food, energy and Na + ingestion, together with urinary Na + excretion, Na + density (Na + intake/energy intake), plasma Na + concentration, SBP, and renal proximal tubule Na + -transporting ATPases. Undernourished rats aged 92 days had only one-third of the control body mass, lower plasma albumin, higher SBP, higher energy intake, and higher positive Na + balance accompanied by decreased plasma Na + concentration. Losartan or Ang-(3–4) normalized SBP, and the combination of the 2 substances induced an accentuated negative Na + balance as a result of strong inhibition of Na + ingestion. Na + density in undernourished rats was higher than in control, irrespective of the treatment, and they had downregulated (Na + +K + )ATPase and upregulated Na + -ATPase in proximal tubule cells, which returned to control levels after Losartan or Ang-(3–4). We conclude that Na + density, not only Na + ingestion, plays a central role in the pathophysiology of elevated SBP in chronically undernourished rats. The observations that Losartan and Ang-(3–4) normalized SBP together with negative Na + balance give support to the proposal that Ang II⇒AT 1 R and Ang II⇒AT 2 R axes have opposite roles within the renin-angiotensin-aldosterone system of undernourished juvenile rats.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0273385
DOI:
10.1371/journal.pone.0273385.g001
DOI:
10.1371/journal.pone.0273385.g002
DOI:
10.1371/journal.pone.0273385.g003
DOI:
10.1371/journal.pone.0273385.g004
DOI:
10.1371/journal.pone.0273385.g005
DOI:
10.1371/journal.pone.0273385.g006
DOI:
10.1371/journal.pone.0273385.g007
DOI:
10.1371/journal.pone.0273385.g008
DOI:
10.1371/journal.pone.0273385.g009
DOI:
10.1371/journal.pone.0273385.g010
DOI:
10.1371/journal.pone.0273385.g011
DOI:
10.1371/journal.pone.0273385.g012
DOI:
10.1371/journal.pone.0273385.g013
DOI:
10.1371/journal.pone.0273385.g014
DOI:
10.1371/journal.pone.0273385.t001
DOI:
10.1371/journal.pone.0273385.t002
DOI:
10.1371/journal.pone.0273385.s001
DOI:
10.1371/journal.pone.0273385.s002
DOI:
10.1371/journal.pone.0273385.r001
DOI:
10.1371/journal.pone.0273385.r002
DOI:
10.1371/journal.pone.0273385.r003
DOI:
10.1371/journal.pone.0273385.r004
DOI:
10.1371/journal.pone.0273385.r005
DOI:
10.1371/journal.pone.0273385.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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