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  • Wiley  (2)
  • Cohen, Koby  (2)
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  • Wiley  (2)
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  • 1
    Online Resource
    Online Resource
    Positive and Negative Effects of Cannabis and Cannabinoids on Health
    Wiley ; 2019
    In:  Clinical Pharmacology & Therapeutics Vol. 105, No. 5 ( 2019-05), p. 1139-1147
    Details
    In: Clinical Pharmacology & Therapeutics, Wiley, Vol. 105, No. 5 ( 2019-05), p. 1139-1147
    Abstract: Cannabis is the most popular illicit drug in the Western world. Repeated cannabis use has been associated with short‐ and long‐term side effects, including respiratory and cardiovascular disorders, cognitive alterations, psychosis, schizophrenia, and mood disorders. However, casual relations between cannabis use and these adverse effects are missing. On the other hand, recent research proposed promising therapeutic potential of cannabinoid‐based drugs for a wide range of medical conditions, including neurological and psychiatric disorders. The current article presents a contemporary review on the adverse effects, safety, and the therapeutic potential of cannabis and cannabinoid‐based drugs. Given the growing popularity in the use of cannabinoid‐based drugs for both recreational and medical purposes and their potential harmful effects, there is a need for further investigation in this field.
    Type of Medium: Online Resource
    ISSN: 0009-9236 , 1532-6535
    URL: Issue
    URL: Article
    DOI: 10.1002/cpt.2019.105.issue-5
    DOI: 10.1002/cpt.1381
    RVK:
    XA 36900
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2040184-X
    SSG: 15,3
    Location Call Number Limitation Availability
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Modulatory effects of cannabinoids on brain neurotransmission
    Wiley ; 2019
    In:  European Journal of Neuroscience Vol. 50, No. 3 ( 2019-08), p. 2322-2345
    Details
    In: European Journal of Neuroscience, Wiley, Vol. 50, No. 3 ( 2019-08), p. 2322-2345
    Abstract: Recreational and chronic cannabis use has been associated with a range of acute and chronic effects including; anti‐nociceptive actions, anxiety, depression, psychotic symptoms and neurocognitive impairments. The mechanisms underlying cannabinoid‐based drugs effects are not fully known but given the neuro‐modulatory functions of the endocannabinoid system, it seems likely that agonistic activity at the cannabinoid type‐1 receptors ( CB 1 ) might modulate the functions of other neurotransmitter systems. The present review has summarized the currently available pre‐clinical and clinical data on the interactions of CB 1 and cannabinoid type‐2 receptors ( CB 2 ) with the central neurotransmitters; dopamine, serotonin, noradrenaline, GABA , glutamate and opioids. Acute and chronic exposures to cannabinoids exert pharmacological alterations in the mammalian brain that have profound implications for our understanding of the neuropharmacology of cannabinoid‐based drugs and their effects on mental health and the brain. A recent emergence uses of cannabis for medical purpose together with legalization and decriminalization of cannabis and increasing use of highly potent synthetic cannabinoids raise a growing concern over the effects of cannabinoids and their interaction with other neurotransmitters on physical and mental health.
    Type of Medium: Online Resource
    ISSN: 0953-816X , 1460-9568
    URL: Issue
    URL: Article
    DOI: 10.1111/ejn.v50.3
    DOI: 10.1111/ejn.14407
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2005178-5
    SSG: 12
    Location Call Number Limitation Availability
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    Online Resource
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