In:
PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 1 ( 2023-1-17), p. e0277571-
Abstract:
Pre-Exposure Prophylaxis (PrEP) for HIV prevention has been implemented in several countries. Previous literature has shown that its cost-effectiveness (and, under some specifications, cost-saving character) is dependent on the reduction in price due to generics, the time-horizon and its effectiveness. The intervention has never been studied in Catalonia after the approval of the PrEP, a territory with extensive implementation. Methods Economic evaluation of the implementation of HIV pre-exposition prophylaxis using administrative data from Men who have Sex with Men (MSM) who receive the treatment (at the generic price) compared with non-implementation. A deterministic compartmental model and a social perspective with a micro-costing approach over the time horizon 2022–2062 are used. A baseline 86% effectiveness of PrEP is assumed. Results Daily oral PrEP is found to be cost-saving: discounted savings in costs are attained after 16 years, and after 40 years they reach 81 million euros. In terms of health indicators, 10,322 additional discounted QALYs are generated by the intervention. Results are sensitive to sexual behavioral patterns among MSM, the price of PrEP (reduced if offered on-demand), its effectiveness and the discount rate. Conclusions The use and promotion of PrEP in Catalonia is predicted to result in substantial health and monetary benefits because of reductions in HIV infections. Short-term investments in the promotion of PrEP will result in important cost-savings in the long term.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0277571
DOI:
10.1371/journal.pone.0277571.g001
DOI:
10.1371/journal.pone.0277571.g002
DOI:
10.1371/journal.pone.0277571.s001
DOI:
10.1371/journal.pone.0277571.s002
DOI:
10.1371/journal.pone.0277571.s003
DOI:
10.1371/journal.pone.0277571.s004
DOI:
10.1371/journal.pone.0277571.s005
DOI:
10.1371/journal.pone.0277571.s006
DOI:
10.1371/journal.pone.0277571.s007
DOI:
10.1371/journal.pone.0277571.s008
DOI:
10.1371/journal.pone.0277571.s009
DOI:
10.1371/journal.pone.0277571.s010
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2267670-3
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