In:
Current Neuropharmacology, Bentham Science Publishers Ltd., Vol. 20, No. 10 ( 2022-10), p. 2001-2012
Abstract:
Olfactory training is the only evidence-based treatment for post-viral olfactory
dysfunction. Smell disorders after SARS-CoV-2 infection have been attributed to neuroinflammatory events within the olfactory bulb and the central nervous system. Therefore, targeting
neuroinflammation is one potential strategy for promoting recovery from post-COVID-19 chronic olfactory dysfunction. Palmitoylethanolamide and luteolin (PEA-LUT) are candidate antiinflammatory/
neuroprotective agents. Objective: To investigate recovery of olfactory function in patients treated with PEA-LUT oral supplements
plus olfactory training versus olfactory training plus placebo. Methods: Multicenter double-blinded randomized placebo-controlled clinical trial was held. Eligible
subjects had prior COVID-19 and persistent olfactory impairment 〉 6 months after follow-up
SARS-CoV-2 negative testing, without prior history of olfactory dysfunction or other sinonasal disorders. Participants were randomized to daily oral supplementation with ultramicronized PEA-LUT
770 mg plus olfactory training (intervention group) or olfactory training with placebo (control). Sniffin’ Sticks assessments were used to test the patients at baseline and 90 days. Results: A total of 185 patients, including intervention (130) and control (55) were enrolled. The intervention
group showed significantly greater improvement in olfactory threshold, discrimination, and identification scores compared to controls (p=0.0001). Overall, 92% of patients in the intervention
group improved versus 42% of controls. Magnitude of recovery was significantly greater in the intervention group versus control (12.8 + 8.2 versus mean 3.2 + 3), with 〉 10-fold higher prevalence
of anosmia in control versus intervention groups at the 90-day endpoint. Conclusion: Among individuals with olfactory dysfunction post-COVID-19, combining PEA-LUT
with olfactory training resulted in greater recovery of smell than olfactory training alone.
Type of Medium:
Online Resource
ISSN:
1570-159X
DOI:
10.2174/1570159X20666220420113513
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2022
detail.hit.zdb_id:
2192352-8
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