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  • S. Karger AG  (3)
  • Chung, Sung Tae  (3)
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  • S. Karger AG  (3)
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  • 1
    Online Resource
    Online Resource
    Evaluation of Interaction between Intrathecal Adenosine and MK801 or NBQX in a Rat Formalin Pain Model
    S. Karger AG ; 2005
    In:  Pharmacology Vol. 75, No. 3 ( 2005), p. 157-164
    Details
    In: Pharmacology, S. Karger AG, Vol. 75, No. 3 ( 2005), p. 157-164
    Abstract: Adenosine and excitatory amino acids have been known to be involved in modulating nociceptive transmission at the spinal level. The authors assessed the characteristics of the interaction of the adenosine-excitatory amino acid antagonist combinations in the spinal cord of rats on the formalin-induced nociception. Intrathecal NMDA antagonist ((5R, 10S)-(+)-5-methyl-10,11-dihydro- 〈 sup 〉 5 〈 /sup 〉 H-dibenzo[a[,]d] cyclohepten-5,10-imine hydrogen maleate, MK801, 30 µg) and AMPA antagonist (2,3-dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[F]quinoxaline-7-sulfonamide, NBQX, 3 µg) decreased the total number of flinches during both phases in the formalin test. Intrathecal adenosine (300 µg) had little effect on the phase 1 flinching response, but decreased the phase 2 response. The fixed dose analysis and the isobolographic analysis revealed that adenosine interacts additively with MK801 and NBQX in the spinal cord.
    Type of Medium: Online Resource
    ISSN: 0031-7012 , 1423-0313
    URL: Article
    DOI: 10.1159/000088345
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2005
    detail.hit.zdb_id: 1483550-2
    SSG: 15,3
    Location Call Number Limitation Availability
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Lack of Reciprocity between Opioid and 5-HT〈sub〉3〈/sub〉 Receptors for Antinociception in Rat Spinal Cord
    S. Karger AG ; 2006
    In:  Pharmacology Vol. 77, No. 4 ( 2006), p. 195-202
    Details
    In: Pharmacology, S. Karger AG, Vol. 77, No. 4 ( 2006), p. 195-202
    Abstract: We examined the properties of the drug interaction between morphine and 5-HT 〈 sub 〉 3 〈 /sub 〉 receptor antagonist at the spinal level. The nociceptive state was induced by subcutaneously injecting formalin solution (5%, 50 µl) into the hindpaw of the rats. Intrathecal morphine and 〈 i 〉 m 〈 /i 〉 -CPBG (5-HT 〈 sub 〉 3 〈 /sub 〉 receptor agonist) dose-dependently decreased the flinching response during phase 1 and phase 2 in the formalin test. Intrathecal 5-HT 〈 sub 〉 3 〈 /sub 〉 receptor antagonists (LY-278,584 and ondansetron) did not reverse the antinociceptive effect of intrathecal morphine. Intrathecal naloxone had little effect on attenuation of the antinociception of intrathecal 〈 i 〉 m 〈 /i 〉 -CPBG. Taken together, no reciprocal interaction was noted between 5-HT 〈 sub 〉 3 〈 /sub 〉 receptor and opioid receptors at the spinal level. Thus, the 5-HT 〈 sub 〉 3 〈 /sub 〉 receptor antagonist may be useful to manage opioid-induced emesis at the spinal level.
    Type of Medium: Online Resource
    ISSN: 0031-7012 , 1423-0313
    URL: Article
    DOI: 10.1159/000094763
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2006
    detail.hit.zdb_id: 1483550-2
    SSG: 15,3
    Location Call Number Limitation Availability
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    Online Resource
  • 3
    Online Resource
    Online Resource
    Roles of Adenosine Receptor Subtypes in the Antinociceptive Effect of Intrathecal Adenosine in a Rat Formalin Test
    S. Karger AG ; 2006
    In:  Pharmacology Vol. 78, No. 1 ( 2006), p. 21-26
    Details
    In: Pharmacology, S. Karger AG, Vol. 78, No. 1 ( 2006), p. 21-26
    Abstract: The contributions of adenosine receptor subtypes to antinociception produced by adenosine were determined at the spinal level. There are 4 types of adenosine receptors, namely A 〈 sub 〉 1 〈 /sub 〉 , A 〈 sub 〉 2A 〈 /sub 〉 , A 〈 sub 〉 2B 〈 /sub 〉 and A 〈 sub 〉 3 〈 /sub 〉 . The authors investigated the properties of the subtypes of spinal adenosine receptors in terms of nociceptive modulation. The nociceptive state was induced by subcutaneously injecting formalin solution (5%, 50 µl) into the hind paws of male Sprague-Dawley rats. After observing the effect of intrathecal adenosine during the formalin test, the effects of intrathecal adenosine A 〈 sub 〉 1 〈 /sub 〉 (CPT), A 〈 sub 〉 2A 〈 /sub 〉 (CSC), A 〈 sub 〉 2B 〈 /sub 〉 (alloxazine) and A 〈 sub 〉 3 〈 /sub 〉 (MRS 1220) receptor antagonists on the action of adenosine were examined. Intrathecal adenosine inhibited phase 2 flinching response without affecting phase 1 response. CPT, CSC, alloxazine and MRS 1220 antagonized the antinociceptive action of adenosine during phase 2 of the formalin test. These results suggest that spinal adenosine A 〈 sub 〉 1 〈 /sub 〉 , A 〈 sub 〉 2A 〈 /sub 〉 , A 〈 sub 〉 2B 〈 /sub 〉 and A 〈 sub 〉 3 〈 /sub 〉 receptors may play an important role in the antinociception of adenosine in the formalin-induced facilitated state.
    Type of Medium: Online Resource
    ISSN: 0031-7012 , 1423-0313
    URL: Article
    DOI: 10.1159/000094762
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2006
    detail.hit.zdb_id: 1483550-2
    SSG: 15,3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
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