In:
International Journal of Cancer, Wiley, Vol. 145, No. 8 ( 2019-10-15), p. 2249-2259
Abstract:
What's new? Though human prostate cancer (PCa) heterogeneity can best be studied using multiple cell types isolated from clinical specimens, the difficulty of establishing cell lines and need for genetic manipulation have hampered this approach. This article describes the establishment and characterization of an epithelium‐like cell line from a prostatectomy specimen without exogenous gene transfer. Not in itself tumorigenic, this new cell line can become highly tumorigenic via cell–cell interaction with aggressive prostate cancer cells. This newly established cell line is thus an ideal model for investigating the mechanism of prostate cancer progression and metastasis.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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