GLORIA

GEOMAR Library Ocean Research Information Access

Ihre E-Mail wurde erfolgreich gesendet. Bitte prüfen Sie Ihren Maileingang.

Leider ist ein Fehler beim E-Mail-Versand aufgetreten. Bitte versuchen Sie es erneut.

Vorgang fortführen?

Exportieren
  • 1
    In: Arthritis & Rheumatology, Wiley, Vol. 67, No. 1 ( 2015-01), p. 74-85
    Kurzfassung: Aminopeptidase N/CD13 (EC 3.4.11.2) is a metalloproteinase expressed by fibroblast‐like synoviocytes (FLS). It has been suggested that CD13 can act chemotactically for T cells in rheumatoid arthritis (RA). We undertook this study to measure CD13 in vivo and in vitro in RA samples and to determine whether CD13 could play a role in the homing of T cells to the RA joint. Methods Interleukin‐17–treated FLS were used to immunize mice, from which a novel anti‐human CD13 monoclonal antibody (mAb), 591.1D7.34, was developed. The mAb 591.1D7.34 and a second anti‐CD13 mAb, WM15, were used to develop a novel enzyme‐linked immunosorbent assay (ELISA) for CD13, and CD13 enzymatic activity was measured in parallel. Chemotaxis of cytokine‐activated T cells was measured by a chemotaxis‐under‐agarose assay. Results We detected substantial amounts of CD13 in synovial fluid (SF), sera, FLS lysates, and culture supernatants by ELISA, with a significant increase in CD13 in RA SF when compared to osteoarthritis SF. CD13 accounted for most but not all of the CD13‐like enzymatic activity in SF. Recombinant human CD13 was chemotactic for cytokine‐activated T cells through a G protein–coupled receptor and contributed to the chemotactic properties of SF independently of enzymatic activity. Conclusion CD13 is released from FLS into culture supernatants and is found in SF. CD13 induces chemotaxis of cytokine‐activated T cells, a T cell population similar to that found in RA synovium. These data suggest that CD13 could play an important role as a T cell chemoattractant, in a positive feedback loop that contributes to RA synovitis.
    Materialart: Online-Ressource
    ISSN: 2326-5191 , 2326-5205
    URL: Issue
    RVK:
    RVK:
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2015
    ZDB Id: 2754614-7
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 2
    Online-Ressource
    Online-Ressource
    Ovid Technologies (Wolters Kluwer Health) ; 2016
    In:  Annals of Surgery Vol. 264, No. 4 ( 2016-10), p. 682-689
    In: Annals of Surgery, Ovid Technologies (Wolters Kluwer Health), Vol. 264, No. 4 ( 2016-10), p. 682-689
    Materialart: Online-Ressource
    ISSN: 0003-4932
    RVK:
    Sprache: Englisch
    Verlag: Ovid Technologies (Wolters Kluwer Health)
    Publikationsdatum: 2016
    ZDB Id: 2002200-1
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 3
    Online-Ressource
    Online-Ressource
    Ovid Technologies (Wolters Kluwer Health) ; 2018
    In:  Annals of Surgery Vol. 268, No. 3 ( 2018-09), p. 513-525
    In: Annals of Surgery, Ovid Technologies (Wolters Kluwer Health), Vol. 268, No. 3 ( 2018-09), p. 513-525
    Kurzfassung: The aim was to validate the new Taiwan Lymphoscintigraphy Staging, correlate it with Cheng Lymphedema Grading (CLG) and evaluate the treatment outcomes of unilateral extremity lymphedema. Background: No consensus has been reached for diagnosis and staging for patients with lymphedema among medical specialties. Methods: We included 285 patients with unilateral extremity lymphedema using lymphoscintigraphy. Lymphoscintigraphy was correlated to clinical symptoms and signs, and classified into normal lymphatic drainage, partial obstruction, and total obstruction. Inter- and intraobserver reliability of Taiwan Lymphoscintigraphy Staging, correlation between Taiwan Lymphoscintigraphy Staging and clinical findings were conducted. Patients were categorized in “surgical” (n = 154) or “nonsurgical” (n = 131) groups for outcome evaluation. Results: Lymphoscintigraphy found 11 patients (3.9%) with normal lymphatic drainage, 128 (44.9%) with partial obstruction, and 146 (51.2%) with total obstruction. Taiwan Lymphoscintigraphy Staging showed high interobserver agreement [intraclass correlation coefficient: 0.89 (95% confidence interval, 0.82–0.94)], and significantly correlated to computed tomography volumetric difference ( r = 0.66, P 〈 0.001) and CLG [intraclass correlation coefficient: 0.79 (95% confidence interval 0.72–0.84)]. At a mean follow-up of 31.2 ± 2.9 months, significant improvement in the circumferential difference (from 23.9% ± 17.6% to 14.6% ± 11.1%; P = 0.03) with a mean circumferential reduction rate of 40.4% ± 4.5% was found in surgical group. At a mean follow-up of 26.6 ± 8.7 months, the nonsurgical group had increase of mean circumferential difference from 24.0% ± 17.2% to 25.3% ± 19.0% ( P = 0.09), with a mean circumferential reduction rate was −1.9% ± 13.0%. Conclusions: The Taiwan Lymphoscintigraphy Staging is a reliable diagnostic tool, correlated with clinical findings and CLG, aiding in the selection of the appropriate treatment to achieve favorable long-term outcomes in unilateral extremity lymphedema.
    Materialart: Online-Ressource
    ISSN: 0003-4932 , 1528-1140
    RVK:
    Sprache: Englisch
    Verlag: Ovid Technologies (Wolters Kluwer Health)
    Publikationsdatum: 2018
    ZDB Id: 2641023-0
    ZDB Id: 2002200-1
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 4
    In: Arthritis Care & Research, Wiley, Vol. 69, No. 7 ( 2017-07), p. 973-981
    Kurzfassung: Rheumatoid arthritis (RA) causes destruction of the metacarpophalangeal (MCP) joints, leading to hand deformities, pain, and loss of function. This study prospectively assessed long‐term functional and health‐related quality‐of‐life outcomes in RA patients with severe deformity at the MCP joints. Methods RA patients between ages 18 to 80 years with severe deformity at the MCP joints were referred to 1 of the 3 study sites. Subjects who elected to undergo silicone metacarpophalangeal joint arthroplasty (SMPA) while continuing with medical management were followed in the SMPA cohort. Subjects who elected to continue with medical management alone without surgery were followed in the non‐SMPA cohort. Objective measurements included grip and pinch strength as well as arc of motion, ulnar drift, and extensor lag of the MCP joints. Patient‐reported outcomes included the Michigan Hand Questionnaire (MHQ) and the Arthritis Impact Measurement Scales questionnaire. Radiographs of SMPA implants were assessed and graded as intact, deformed, or fractured. Results MHQ scores showed large improvements post‐SMPA, and baseline‐adjusted expected outcomes in the SMPA group were significantly better at year 7 in function, aesthetics, satisfaction, and overall score compared to non‐SMPA. SMPA subjects did not improve in grip or pinch strength, but achieved significant improvement and maintained the improvement long term in ulnar drift and extensor lag. Conclusion Benefits of the SMPA procedure are maintained over 7 years with low rates of implant fracture or deformity. Non‐SMPA patients remained stable in their hand function over the 7‐year study duration.
    Materialart: Online-Ressource
    ISSN: 2151-464X , 2151-4658
    URL: Issue
    RVK:
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2017
    ZDB Id: 2016713-1
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 5
    Online-Ressource
    Online-Ressource
    Elsevier BV ; 2018
    In:  The American Journal of Surgery Vol. 216, No. 3 ( 2018-09), p. 551-557
    In: The American Journal of Surgery, Elsevier BV, Vol. 216, No. 3 ( 2018-09), p. 551-557
    Materialart: Online-Ressource
    ISSN: 0002-9610
    RVK:
    Sprache: Englisch
    Verlag: Elsevier BV
    Publikationsdatum: 2018
    ZDB Id: 2003374-6
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 6
    In: Arthritis & Rheumatology, Wiley, Vol. 71, No. 8 ( 2019-08), p. 1241-1251
    Kurzfassung: To explore the intrinsic role of inhibitor of DNA binding 1 ( ID ‐1) in rheumatoid arthritis ( RA ) fibroblast‐like synoviocytes ( FLS ) and to investigate whether ID ‐1 is citrullinated and autoantigenic in RA . Methods RA patient serum ID ‐1 levels were measured before and after infliximab treatment. RA FLS were transfected with a clustered regularly interspaced short palindromic repeat ( CRISPR )/ CRISPR ‐associated protein 9 construct targeting ID ‐1 to examine the effects of ID ‐1 deletion. RA synovial fluid ( SF ) and homogenized synovial tissue ( ST ) were immunoprecipitated for ID ‐1 and measured for citrullinated residues using an enzyme‐linked immunosorbent assay and Western blotting. Liquid chromatography tandem mass spectrometry ( LC ‐ MS / MS ) was performed on in vitro–citrullinated recombinant human ID ‐1 (cit– ID ‐1) to localize the sites of citrullination. Normal and RA sera and SF were analyzed by immunodot blotting for anti–citrullinated protein antibodies ( ACPA s) to cit– ID ‐1. Results RA patient serum ID ‐1 levels positively correlated with several disease parameters and were reduced after infliximab treatment. RA FLS displayed reduced growth and a robust increase in interleukin‐6 ( IL ‐6) and IL ‐8 production upon deletion of ID ‐1. ID ‐1 immunodepletion significantly reduced the levels of citrullinated residues in RA SF , and citrullinated ID ‐1 was detected in homogenized RA ST (n = 5 samples; P 〈 0.05). Immunodot blot analyses revealed ACPA s to cit– ID ‐1 but not to native ID ‐1, in RA peripheral blood ( PB ) sera (n = 30 samples; P 〈 0.001) and SF (n = 18 samples; P 〈 0.05) but not in normal PB sera. Following analyses of LC ‐ MS / MS results for citrullination sites and corresponding reactivity in immunodot assays, we determined the critical arginines in ID ‐1 for autoantigenicity: R33, R52, and R121. Conclusion Novel roles of ID ‐1 in RA include regulation of FLS proliferation and cytokine secretion as well as autoantigenicity following citrullination.
    Materialart: Online-Ressource
    ISSN: 2326-5191 , 2326-5205
    URL: Issue
    RVK:
    RVK:
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2019
    ZDB Id: 2754614-7
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 7
    Online-Ressource
    Online-Ressource
    Ovid Technologies (Wolters Kluwer Health) ; 2015
    In:  Clinical Orthopaedics & Related Research Vol. 473, No. 11 ( 2015-11), p. 3549-3563
    In: Clinical Orthopaedics & Related Research, Ovid Technologies (Wolters Kluwer Health), Vol. 473, No. 11 ( 2015-11), p. 3549-3563
    Materialart: Online-Ressource
    ISSN: 0009-921X
    RVK:
    Sprache: Englisch
    Verlag: Ovid Technologies (Wolters Kluwer Health)
    Publikationsdatum: 2015
    ZDB Id: 2018318-5
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 8
    Online-Ressource
    Online-Ressource
    Ovid Technologies (Wolters Kluwer Health) ; 2015
    In:  Journal of Bone and Joint Surgery Vol. 97, No. 5 ( 2015-03-4), p. 403-410
    In: Journal of Bone and Joint Surgery, Ovid Technologies (Wolters Kluwer Health), Vol. 97, No. 5 ( 2015-03-4), p. 403-410
    Materialart: Online-Ressource
    ISSN: 0021-9355 , 1535-1386
    RVK:
    Sprache: Englisch
    Verlag: Ovid Technologies (Wolters Kluwer Health)
    Publikationsdatum: 2015
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 9
    Online-Ressource
    Online-Ressource
    Journal of Neurosurgery Publishing Group (JNSPG) ; 2018
    In:  Journal of Neurosurgery: Pediatrics Vol. 21, No. 2 ( 2018-02), p. 178-184
    In: Journal of Neurosurgery: Pediatrics, Journal of Neurosurgery Publishing Group (JNSPG), Vol. 21, No. 2 ( 2018-02), p. 178-184
    Kurzfassung: The use of nerve transfers versus nerve grafting for neonatal brachial plexus palsy (NBPP) remains controversial. In adult brachial plexus injury, transfer of an ulnar fascicle to the biceps branch of the musculocutaneous nerve (Oberlin transfer) is reportedly superior to nerve grafting for restoration of elbow flexion. In pediatric patients with NBPP, recovery of elbow flexion and forearm supination is an indicator of resolved NBPP. Currently, limited evidence exists of outcomes for flexion and supination when comparing nerve transfer and nerve grafting for NBPP. Therefore, the authors compared 1-year postoperative outcomes for infants with NBPP who underwent Oberlin transfer versus nerve grafting. METHODS This retrospective cohort study reviewed patients with NBPP who underwent Oberlin transfer (n = 19) and nerve grafting (n = 31) at a single institution between 2005 and 2015. A single surgeon conducted intraoperative exploration of the brachial plexus and determined the surgical nerve reconstruction strategy undertaken. Active range of motion was evaluated preoperatively and postoperatively at 1 year. RESULTS No significant difference between treatment groups was observed with respect to the mean change (pre- to postoperatively) in elbow flexion in adduction and abduction and biceps strength. The Oberlin transfer group gained significantly more supination (100° vs 19°; p 〈 0.0001). Forearm pronation was maintained at 90° in the Oberlin transfer group whereas it was slightly improved in the grafting group (0° vs 32°; p = 0.02). Shoulder, wrist, and hand functions were comparable between treatment groups. CONCLUSIONS The preliminary data from this study demonstrate that the Oberlin transfer confers an advantageous early recovery of forearm supination over grafting, with equivalent elbow flexion recovery. Further studies that monitor real-world arm usage will provide more insight into the most appropriate surgical strategy for NBPP.
    Materialart: Online-Ressource
    ISSN: 1933-0707 , 1933-0715
    RVK:
    Sprache: Unbekannt
    Verlag: Journal of Neurosurgery Publishing Group (JNSPG)
    Publikationsdatum: 2018
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 10
    Online-Ressource
    Online-Ressource
    The Journal of Rheumatology ; 2015
    In:  The Journal of Rheumatology Vol. 42, No. 3 ( 2015-03), p. 429-436
    In: The Journal of Rheumatology, The Journal of Rheumatology, Vol. 42, No. 3 ( 2015-03), p. 429-436
    Kurzfassung: To examine the rate and variation in rheumatoid arthritis (RA)-related hand and wrist surgery among Medicare (elderly) beneficiaries in the United States, and to identify the patient and provider factors that influence surgical rates. Methods. Using the 2006–2010 100% Medicare claims data of beneficiaries with RA diagnosis, we examined rates of rheumatoid hand and wrist arthroplasty, arthrodesis, and hand tendon reconstruction in the United States. We used multivariate logistic regression models to examine variation in receipt of surgery by patient and regional characteristics (density of providers, intensity of use of biologic disease-modifying antirheumatic drugs). Results. Between 2006 and 2010, the annual rate of RA-related hand and wrist arthroplasty or arthrodesis was 23.1 per 10,000 patients, and the annual rate of hand tendon reconstruction was 4.2 per 10,000 patients. The rates of surgery varied 9-fold across hospital referral regions in the United States. Younger patient age, female sex, white race, higher socioeconomic status (SES), and rural residence were associated with a higher likelihood of undergoing arthroplasty and arthrodesis. We observed a significant decline in rate of arthroplasty and arthrodesis with increasing density of rheumatologists. Tendon reconstruction was not influenced by provider factors, but was correlated with age, race, SES, and rural status of the patients. Conclusion. Surgical reconstruction of rheumatoid hand deformities varies widely across the United States, driven by both regional availability of subspecialty care in rheumatology and individual patient factors.
    Materialart: Online-Ressource
    ISSN: 0315-162X , 1499-2752
    RVK:
    Sprache: Englisch
    Verlag: The Journal of Rheumatology
    Publikationsdatum: 2015
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
Schließen ⊗
Diese Webseite nutzt Cookies und das Analyse-Tool Matomo. Weitere Informationen finden Sie hier...