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  • 1
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    Reference interval and the role of plasma oligomeric beta amyloid in screening of risk groups for cognitive dysfunction at health checkups
    Wiley ; 2021
    In:  Journal of Clinical Laboratory Analysis Vol. 35, No. 9 ( 2021-09)
    Details
    In: Journal of Clinical Laboratory Analysis, Wiley, Vol. 35, No. 9 ( 2021-09)
    Abstract: Alzheimer's disease (AD) has a prolonged preclinical stage characterized by cognitive dysfunction. Simple, reliable, and noninvasive biomarkers reflecting the pathogenesis of AD are needed for screening cognitive dysfunction in primary health care. The aims of this study were to determine (1) the potential utility of the Multimer Detection System‐Oligomeric Amyloid‐β (MDS‐OAβ) value in cognitive assessments and (2) the reference interval (RI) of plasma MDS‐OAβ values in the general population. Methods This prospective study consecutively recruited 1,594 participants who underwent health checkups including cognitive function examination at 16 health‐promotion centers in Korea between December 2020 and January 2021. The inBlood TM OAβ test (PeopleBio, Gyeonggi‐do, Republic of Korea) was utilized to quantify MDS‐OAβ values in plasma. The reference subjects were obtained among those with normal general cognition on cognitive screening tools. RIs were established according to the CLSI C28‐A3 guidelines. Results The median MDS‐OAβ value was higher in subjects with Korean Dementia Screening Questionnaire‐Cognition (KDSQ‐C) scores ≥8 than in those with KDSQ‐C scores of 6–7 ( P  = 0.013). The median MDS‐OAβ value was higher in subjects with Mini‐Mental State Examination for Dementia Screening (MMSE‐DS) scores of 21–26 than in those with MMSE‐DS scores ≥27 ( P  = 0.011). The RI (one‐side upper 95th percentile) of the MDS‐OAβ value was 0.80 ng/mL (95% confidence interval = 0.78–0.82) in those aged ≥50 years. Conclusions The plasma MDS‐OAβ value reflects cognitive function as assessed using the KDSQ‐C and MMSE‐DS. RIs obtained from a large and cognitively healthy community‐based sample are presented.
    Type of Medium: Online Resource
    ISSN: 0887-8013 , 1098-2825
    URL: Issue
    URL: Article
    DOI: 10.1002/jcla.v35.9
    DOI: 10.1002/jcla.23933
    Language: English
    Publisher: Wiley
    Publication Date: 2021
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  • 2
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    Antibody response after two doses of homologous or heterologous SARS‐CoV‐2 vaccines in healthcare workers at health promotion centers: A prospective observational study
    Wiley ; 2022
    In:  Journal of Medical Virology Vol. 94, No. 10 ( 2022-10), p. 4719-4726
    Details
    In: Journal of Medical Virology, Wiley, Vol. 94, No. 10 ( 2022-10), p. 4719-4726
    Abstract: Assaying of anti‐spike‐protein receptor‐binding domain (S‐RBD) antibodies are used to aid evaluations of the immune statuses of individuals. The aim of this study was to determine the antibody response after two doses of homologous or heterologous severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) vaccines and to identify the factors affecting this response among healthcare workers (HCWs) at health promotion centers. In this prospective observational study, 1095 consenting HCWs were recruited from 16 health checkup centers and were tested at T0 (day of first dose), T1‐1 (1 month after first dose), T2‐0 (day of second dose), T2‐1 (1 month after second dose), and T2‐3 (3 months after second dose). SARS‐CoV‐2 antibodies were measured using a chemiluminescence microparticle immunoassay with SARS‐CoV‐2 IgG II Quant in the ARCHITECT system (Abbott Diagnostics). At T1‐1, anti‐SARS‐CoV‐2 S‐RBD IgG levels were significantly higher in participants who received messenger RNA (mRNA) vaccines than in those who received viral vector vaccines ( p  〈  0.001). At T2‐1, anti‐SARS‐CoV‐2 S‐RBD IgG levels were about 10 times higher than at T1‐1 in participants who received homologous mRNA vaccines, which decreased to a third of those at T2‐3. Anti‐SARS‐CoV‐2 S‐RBD IgG levels were highest among those who received homologous mRNA vaccines, followed by heterologous mRNA viral vector vaccines and homologous viral vector vaccines at T2‐3 ( p  〈  0.001). In a multivariable linear regression analysis, being female, taking at least one mRNA vaccine, and having a history of recovery from coronavirus disease 2019 (COVID‐19) were significantly associated with anti‐S‐RBD levels. Anti‐SARS‐CoV‐2 S‐RBD IgG levels were decreased at 3 months after two‐dose vaccinations and were associated with sex, vaccine type, and COVID‐19 history.
    Type of Medium: Online Resource
    ISSN: 0146-6615 , 1096-9071
    URL: Issue
    URL: Article
    DOI: 10.1002/jmv.v94.10
    DOI: 10.1002/jmv.27911
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 752392-0
    detail.hit.zdb_id: 1475090-9
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  • 3
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    Distribution of hemoglobin levels and prevalence of anemia according to sex, age group, and region in 13 Korean cities
    Wiley ; 2020
    In:  International Journal of Laboratory Hematology Vol. 42, No. 2 ( 2020-04), p. 223-229
    Details
    In: International Journal of Laboratory Hematology, Wiley, Vol. 42, No. 2 ( 2020-04), p. 223-229
    Abstract: The distribution of hemoglobin (Hb) levels and the prevalence of anemia are significant public health indicators. The aims of this study were to determine the distribution of Hb levels and the prevalence of anemia according to sex, age group, and region throughout Korea. Methods The study analyzed data on 1 159 298 subjects who received health checkups at 16 health‐promotion centers in 13 Korean cities during 2018. Anemia and its severity were defined according to the World Health Organization classification for Hb levels as follows: mild anemia (11‐12.9 g/dL in males and 11‐11.9 g/dL in females), moderate anemia (10‐10.9 g/dL in both sexes), and severe anemia ( 〈 10.0 g/dL in both sexes). Results The Hb level in the general sample was lower in females (13.25 ± 1.13 g/dL, mean ± SD) than in males (15.29 ± 1.22 g/dL). The overall prevalence of anemia was 6.0% (2.98% in males and 8.56% in females), and the prevalence of severe anemia was 0.92% (0.23% in males and 1.51% in females). While the prevalence of anemia increased monotonically with age in males, it was bimodal in females with two peaks at 40‐49 years and ≥80 years. The highest prevalence of anemia in females aged 40‐49 years was attributed to microcytic anemia, while increases in anemia prevalence in males aged ≥50 years and females aged ≥70 years were attributed to macrocytic anemia. Conclusion The distribution of Hb levels and the prevalence of anemia overall and by severity differ according to sex, age group, and region throughout Korea.
    Type of Medium: Online Resource
    ISSN: 1751-5521 , 1751-553X
    URL: Issue
    URL: Article
    DOI: 10.1111/ijlh.v42.2
    DOI: 10.1111/ijlh.13160
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2268600-9
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  • 4
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    Reference interval and the role of soluble suppression of tumorigenicity 2 (sST2) in subclinical cardiac dysfunction at health checkups
    Wiley ; 2020
    In:  Journal of Clinical Laboratory Analysis Vol. 34, No. 11 ( 2020-11)
    Details
    In: Journal of Clinical Laboratory Analysis, Wiley, Vol. 34, No. 11 ( 2020-11)
    Abstract: Soluble ST2 (sST2) is known to predict adverse outcomes and death in individuals with established heart failure. However, the role of sST2 testing in the general population has not been established. The aims of this study were to determine the reference interval (RI) and the clinical utility of sST2 in subclinical cardiac dysfunction in general population. Methods This cross‐sectional study consecutively selected 41,806 general subjects at health checkups who underwent echocardiography and sST2 testing at 16 health promotion centers in 13 Korean cities. The reference subjects were obtained among those with normal findings in echocardiography. Sex‐specific RIs were established according to the CLSI C28‐A3 guidelines. sST2 was measured using immunoassay with the Presage ST2 assay (Critical Diagnostics). Results In the general subjects, age, sex, BMI, systolic blood pressure, blood glucose, creatinine, liver function, and triglycerides were associated with the sST2 levels. The RI for sST2 was higher in males (≤49.6 ng/mL, 95% CI = 48.5‐51.5) than in females (≤44.5 ng/mL, 95% CI = 43.5‐45.6) and higher in subjects aged  〈  40 years than ≥ 40 years in both sexes. The sST2 levels were 29.1 ± 10.7 (mean ± SD) and 29.1 ± 14.4 ng/mL in the groups with normal cardiac function and subclinical cardiac dysfunction, respectively. The sST2 level was not associated with subclinical cardiac dysfunction (odd ratio = 1.002, P  = .13). Conclusions RIs obtained from a large and echocardiography‐proven healthy community‐based sample are presented. Subclinical cardiac dysfunction was associated with older age, male sex, and metabolic factors but not with the sST2 level.
    Type of Medium: Online Resource
    ISSN: 0887-8013 , 1098-2825
    URL: Issue
    URL: Article
    DOI: 10.1002/jcla.v34.11
    DOI: 10.1002/jcla.23461
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2001635-9
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  • 5
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    Establishment and validation of reference intervals for tumor markers (AFP, CEA, CA19‐9, CA15‐3, CA125, PSA, HE4, Cyfra 21‐1, and ProGRP) in primary care centers in Korea: A cross‐sectional retrospective study
    Wiley ; 2023
    In:  Health Science Reports Vol. 6, No. 2 ( 2023-02)
    Details
    In: Health Science Reports, Wiley, Vol. 6, No. 2 ( 2023-02)
    Abstract: The reference interval (RI) for a tumor marker may vary between populations, detection systems, and the methods used to obtain their values. The aims of this study were to establish age‐ and sex‐specific RIs for the following nine common tumor markers and to validate the established RIs in Korean adults: alpha fetoprotein (AFP), carcinoembryonic antigen (CEA), cancer antigen (CA) 19‐9, CA15‐3, CA125, Human epididymis protein 4 (HE4), total prostate specific antigen, cytokeratin fragment (Cyfra) 21‐1, and progastrin‐releasing peptide (ProGRP). Methods This cross‐sectional study consecutively selected 214,159 individuals (aged 18–98 years) who underwent health checkups at 16 health‐promotion centers in 13 Korean cities. Finally, 62,752 examinees were used to establish the RIs after removing outliers. RIs were established using an indirect method according to the CLSI EP28‐A3C guideline. The established RIs were validated by calculating the proportion of individuals outside each RI. Results Sex‐related differences were observed for AFP, CEA, CA19‐9, Cyfra 21‐1, and ProGRP ( p   〈  0.05): AFP, CEA and Cyfra 21‐1 were higher in males, and CA19‐9 and proGRP were higher in females. Most of the tumor markers except CA15‐3 and CA125 increased with age: CA125 decreased at ≥50 years of age ( p   〈  0.05), while CA15‐3 did not vary with age. Less than 5% of subjects were outside all RIs (the 2.5th and 97.5th percentiles) established in the present study. Meanwhile, less than 3% of the healthy reference subjects fell outside the current and manufacturers' RIs of all tumor markers except Cyfra 21‐1. Conclusion This study has determined age‐ and sex‐specific RIs for nine common tumor markers in the healthy Korean population, which could be useful for clinicians making clinical decisions and assessments.
    Type of Medium: Online Resource
    ISSN: 2398-8835 , 2398-8835
    URL: Issue
    URL: Article
    DOI: 10.1002/hsr2.v6.2
    DOI: 10.1002/hsr2.1107
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2927182-4
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  • 6
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    Diagnostic performance of Mac‐2 binding protein glycosylation isomer (M2BPGi) in screening liver fibrosis in health checkups
    Wiley ; 2020
    In:  Journal of Clinical Laboratory Analysis Vol. 34, No. 8 ( 2020-08)
    Details
    In: Journal of Clinical Laboratory Analysis, Wiley, Vol. 34, No. 8 ( 2020-08)
    Abstract: Mild‐to‐moderate fibrosis is rarely diagnosed because the disease is asymptomatic in the early stage. The serum level of Mac‐2 binding protein glycosylation isomer (M2BPGi) has been found to increase with the severity of liver fibrosis. The aim of this study was to determine the diagnostic performance of M2BPGi in screening liver fibrosis using magnetic resonance elastography (MRE) as a reference standard and to compare it with using the aspartate aminotransferase‐to‐platelet ratio (APRI) and the Fibrosis‐4 index (FIB‐4) in health checkups. Methods This cross‐sectional study consecutively selected subjects at health examinations who underwent MRE and M2BPGi testing at eight health promotion centers in Korea between January and September 2019. The serum M2BPGi level was measured using the chemiluminescence enzyme immunoassay method. The measured levels were indexed using the cutoff index (COI). COI values of M2BPGi were compared with the MRE results. Results The median (interquartile) values of COI for fibrosis stages F0 (normal liver stiffness), F1 (mild fibrosis), F2 (significant fibrosis), and ≥F3 (advanced fibrosis) were 0.49 (0.34‐0.61), 0.48 (0.38‐0.68), 0.64 (0.43‐1.03), and 1.01 (0.75‐1.77), respectively ( P   〈  .0001). The AUCs of the COI for the screening of fibrosis stage ≥F1, ≥F2, and ≥F3 were 0.591, 0.698, and 0.853, respectively. Using a threshold of 0.75 for COI to exclude advanced fibrosis had a sensitivity, specificity, and negative predictive value of 80.0%, 77.9%, and 98.9%, respectively. The AUC for excluding advanced fibrosis was better for M2BPGi than for FIB‐4 and APRI. Conclusion Serum M2BPGi was useful for screening significant and advanced fibrosis in health checkups.
    Type of Medium: Online Resource
    ISSN: 0887-8013 , 1098-2825
    URL: Issue
    URL: Article
    DOI: 10.1002/jcla.v34.8
    DOI: 10.1002/jcla.23316
    Language: English
    Publisher: Wiley
    Publication Date: 2020
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  • 7
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    Associations of complete blood count parameters with pancreatic beta‐cell function and insulin resistance in prediabetes and type 2 diabetes mellitus
    Wiley ; 2022
    In:  Journal of Clinical Laboratory Analysis Vol. 36, No. 6 ( 2022-06)
    Details
    In: Journal of Clinical Laboratory Analysis, Wiley, Vol. 36, No. 6 ( 2022-06)
    Abstract: Previous studies found controversial associations of CBC parameters with pancreatic beta‐cell function (BCF) and insulin resistance (IR). The aim of this was to determine the independent associations of CBC parameters with BCF and IR in prediabetes and type 2 diabetes mellitus (T2DM). Methods This study selected subjects who underwent health checkups at 16 health‐promotion centers in 13 Korean cities during 2021. The subjects comprised 1470 patients with normoglycemia, 1124 with prediabetes, and 396 with T2DM. BCF and IR were assessed using the homeostasis model assessment (HOMA)‐β and HOMA‐IR, respectively. Correlation and multiple linear regression analyses were used to determine the correlation between CBC parameters and HOMA. Results While HOMA‐IR gradually increased according to red blood cell count quartiles (1.22, 1.40, 1.47, and 1.91, in the first, second, third, and fourth quartiles, respectively; p 〈 0.001), there was no correlation after adjusting for waist circumference (WC) and HbA1c. The red blood cell distribution width (RDW) was associated with HOMA‐ β [coefficient ( β ) = 15.527, p = 0.002], but not with HOMA‐IR. White blood cells (WBCs) were associated with HOMA‐IR and HOMA‐ β , which was stronger in HOMA‐β ( β = 0.505 vs 15.171, p = 0.002) after adjusting for WC and HbA1c. The platelet count was correlated with HOMA‐IR and HOMA‐β, which only remained in HOMA‐β ( β = 15.581, p = 0.002) after adjusting for WC and HbA1c. Conclusion RDW, WBC, and platelet counts were independently associated with only HOMA‐β in prediabetes and T2DM. This suggests that these CBC parameters could represent BCF in prediabetes and T2DM.
    Type of Medium: Online Resource
    ISSN: 0887-8013 , 1098-2825
    URL: Issue
    URL: Article
    DOI: 10.1002/jcla.v36.6
    DOI: 10.1002/jcla.24454
    Language: English
    Publisher: Wiley
    Publication Date: 2022
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  • 8
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    The usefulness of the estimated average glucose/fasting blood glucose ratio for pancreatic β‐cell function assessment in hyperglycemia during health checkups
    Wiley ; 2022
    In:  Journal of Clinical Laboratory Analysis Vol. 36, No. 10 ( 2022-10)
    Details
    In: Journal of Clinical Laboratory Analysis, Wiley, Vol. 36, No. 10 ( 2022-10)
    Abstract: Type 2 diabetes (T2DM) is a disease marked by inadequate insulin secretion by pancreatic beta‐cell function (BCF) failure and insulin resistance (IR). Assessing and managing the BCF and IR should be started early to prevent or delay the progression of the disease. The aim of this study was to determine the usefulness of the estimated average glucose (eAG)/fasting blood glucose (FBG) ratio for pancreatic BCF in hyperglycemia. Methods This cross‐sectional study consecutively selected 10,594 subjects who underwent a health checkup at 16 health checkup centers in 13 Korean cities between 2019 and 2021. The subjects consisted of 3003 patients with normoglycemia, 3413 with impaired fasting glucose and 4178 with T2DM. The eAG was calculated using Nathan's regression equation. BCF and IR were estimated by the homeostasis model assessment (HOMA)‐β and HOMA‐IR, respectively. Multivariate (adjusted) regression analysis was performed to evaluate the association between the eAG/FBG ratio and HOMA. Results The median values among FBG groups for the eAG/FBG ratio, HOMA‐β, ‐IR and insulin differed significantly ( p   〈  0.001). The second‐, third‐ and fourth‐quartile groups of the eAG/FBG ratio had positive higher correlation coefficients [9.533, 10.080 and 12.021, respectively (all p   〈  0.001)] for HOMA‐β than the first quartile group, and higher negative coefficients for HOMA‐IR [−0.696, −0.727 and −0.598, respectively (all p  = 0.001)]. Conclusion The eAG/FBG ratio was significantly correlated with both HOMA‐β and ‐IR, which suggests that eAG/FBG ratio reveals BCF and IR in hyperglycemia. Measurement of this ratio could be useful for monitoring BCF and IR in prediabetes and T2DM.
    Type of Medium: Online Resource
    ISSN: 0887-8013 , 1098-2825
    URL: Issue
    URL: Article
    DOI: 10.1002/jcla.v36.10
    DOI: 10.1002/jcla.24693
    Language: English
    Publisher: Wiley
    Publication Date: 2022
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  • 9
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    Negative cilia concept for thromboresistance: Synergistic effect of PEO and sulfonate groups grafted onto polyurethanes
    Wiley ; 1991
    In:  Journal of Biomedical Materials Research Vol. 25, No. 5 ( 1991-05), p. 561-575
    Details
    In: Journal of Biomedical Materials Research, Wiley, Vol. 25, No. 5 ( 1991-05), p. 561-575
    Type of Medium: Online Resource
    ISSN: 0021-9304 , 1097-4636
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.1002/jbm.v25:5
    DOI: 10.1002/(ISSN)1097-4636
    DOI: 10.1002/jbm.820250502
    Language: English
    Publisher: Wiley
    Publication Date: 1991
    detail.hit.zdb_id: 2176174-7
    SSG: 12
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  • 10
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    Prevalence of monoclonal gammopathy of undetermined significance in an elderly urban Korean population
    Wiley ; 2011
    In:  American Journal of Hematology Vol. 86, No. 9 ( 2011-09), p. 752-755
    Details
    In: American Journal of Hematology, Wiley, Vol. 86, No. 9 ( 2011-09), p. 752-755
    Type of Medium: Online Resource
    ISSN: 0361-8609
    URL: Article
    DOI: 10.1002/ajh.22095
    Language: English
    Publisher: Wiley
    Publication Date: 2011
    detail.hit.zdb_id: 1492749-4
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