In:
Journal of Magnetic Resonance Imaging, Wiley, Vol. 35, No. 5 ( 2012-05), p. 1179-1186
Abstract:
To compare the diagnostic performance of a diffusion‐weighted imaging (DWI) dataset and a gadofluorine M‐enhanced imaging dataset for identifying lymph node (LN) metastases in a rabbit rectal cancer model. Materials and Methods: VX2 carcinomas were injected into the rectum of 26 rabbits. Four weeks later, T2‐weighted imaging (T2WI), pre‐T1WI, DWI, and post‐T1WI were performed. Two radiologists independently reviewed the DWI set (T2WI, pre‐T1WI, DWI) and the gadofluorine M set (T2WI, pre‐ and post‐T1WI) and recorded their confidence scores for LN metastasis on a per‐LN basis. Receiver operating characteristic (ROC) analysis was performed to compare the area under the ROC curve (A z ) of the two imaging sets. Histopathologic results were used as the reference standard. Results: The A z and sensitivity of the gadofluorine M set were comparable to those of the DWI set (A z , for reader 1, 0.849, 0.829, P = 0.571; for reader 2, 0.923, 0.876, P = 0.212; sensitivity, for reader 1, 97%, 97%; for reader 2, 97%, 92%, P = 0.304). The specificity of the former was greater than that of the latter (for reader 1, 65%, 53%, P = 0.0003; for reader 2, 81%, 68%, P = 0.01). Conclusion: Gadofluorine M‐enhanced images provided greater specificity than DWI for identifying LN metastases, whereas the A z and sensitivity of the former were comparable to those of the latter. J. Magn. Reson. Imaging 2012;35:1179‐1186. © 2012 Wiley Periodicals, Inc.
Type of Medium:
Online Resource
ISSN:
1053-1807
,
1522-2586
Language:
English
Publisher:
Wiley
Publication Date:
2012
detail.hit.zdb_id:
1497154-9
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