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  • Wiley  (11)
  • Choi, Kee Don  (11)
  • 2015-2019  (11)
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  • Wiley  (11)
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  • 2015-2019  (11)
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  • 1
    Online Resource
    Online Resource
    Effective endoscopic treatment of Mallory–Weiss syndrome using Glasgow‐Blatchford score and Forrest classification
    Wiley ; 2016
    In:  Journal of Digestive Diseases Vol. 17, No. 10 ( 2016-10), p. 676-684
    Details
    In: Journal of Digestive Diseases, Wiley, Vol. 17, No. 10 ( 2016-10), p. 676-684
    Abstract: There is limited data on whether scoring systems can be used to predict clinical outcomes in patients with upper gastrointestinal bleeding due to Mallory–Weiss syndrome (MWS). We aimed to evaluate whether the Glasgow‐Blatchford score (GBS) could be effective in predicting clinical outcomes of bleeding MWS and to investigate the predictive ability of the Forrest classification for rebleeding and assess the effective endoscopic modalities for bleeding control in MWS. Methods From January 2004 to December 2012 168 patients were diagnosed with MWS in the Asan Medical Center Emergency Department. We analyzed their clinical outcomes, including endoscopic treatment, transfusion and admission as well as the rates of rebleeding and mortality using GBS and the Forrest classification, retrospectively. Results Endoscopic treatment was applied to patients. The GBS was significantly higher in patients treated with endoscopic therapy than in the conservative treatment group (6.8 ± 3.7 vs 5.1 ± 4.7, P =  0.011). In patients with a GBS of 〉 6 the rates of endoscopic treatment and rebleeding and the need for transfusion and admission were significantly higher (all P 〈  0.05). The Forrest classification was able to predict recurrent bleeding (area under the receiver operating characteristic curve 0.723, 95% confidence interval 0.609–0.836, P  = 0.025). Hemoclip‐based therapy and band ligation achieved higher success rates than did injection therapy alone in preventing rebleeding (96.4%, 88.9% and 71.4%, P =  0.013). Conclusion In MWS, GBS might be useful for predicting clinical outcomes and the Forrest classification in predicting recurrent bleeding.
    Type of Medium: Online Resource
    ISSN: 1751-2972 , 1751-2980
    URL: Issue
    URL: Article
    DOI: 10.1111/cdd.2016.17.issue-10
    DOI: 10.1111/1751-2980.12409
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2317117-0
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  • 2
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    Superior clinical outcomes of peroral endoscopic myotomy compared with balloon dilation in all achalasia subtypes
    Wiley ; 2019
    In:  Journal of Gastroenterology and Hepatology Vol. 34, No. 4 ( 2019-04), p. 659-665
    Details
    In: Journal of Gastroenterology and Hepatology, Wiley, Vol. 34, No. 4 ( 2019-04), p. 659-665
    Abstract: Optimal treatment modalities for each of the three subtypes of achalasia are still under debate. Differences in prognosis and long‐term outcomes between peroral endoscopic myotomy (POEM) and balloon dilation (BD) are also unclear. We aimed to compare the treatment outcomes of BD and POEM in each subtype of achalasia by using information from the manometry database of a tertiary referral center in Korea. Methods Data from 5207 esophageal manometry procedures performed between 1989 and 2016 were analyzed. The medical records and results of esophagography and esophagogastroduodenoscopy were also reviewed. Results We identified 264 patients (116 men and 148 women) with diagnosis of achalasia during the study period. POEM and BD were carried out on 64 and 177 patients, respectively. There was a significant difference in the time to relapse between the POEM group and the BD group ( P  = 0.002). At the 24‐month follow‐up, the clinical success rates of POEM and BD were 91.8% and 68.0%, respectively. The hazard ratio of symptom return was 6.54 for BD compared with POEM (95% confidence interval 2.12–20.22, P  = 0.001). After a follow‐up period of 24 months, the success rate of POEM was significantly higher than that of BD for all subtypes of achalasia. However, only that of types I and II was statistically significant (type 1: 92.0% vs 51.1%, P  = 0.004; type 2: 92.3% vs 59.8%, P  = 0.007; and type3: 91.7% vs 55.6%, P  = 0.051). Conclusions Peroral endoscopic myotomy was more effective than BD in providing mid‐long‐term remission in patients with all manometric subtypes of achalasia.
    Type of Medium: Online Resource
    ISSN: 0815-9319 , 1440-1746
    URL: Issue
    URL: Article
    DOI: 10.1111/jgh.2019.34.issue-4
    DOI: 10.1111/jgh.14616
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2006782-3
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  • 3
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    Nationwide antibiotic resistance mapping of Helicobacter pylori in Korea: A prospective multicenter study
    Wiley ; 2019
    In:  Helicobacter Vol. 24, No. 4 ( 2019-08)
    Details
    In: Helicobacter, Wiley, Vol. 24, No. 4 ( 2019-08)
    Abstract: The eradication rates for Helicobacter pylori have decreased in Korea although the prevalence of this bacterium has also decreased. Antibiotic resistance is likely to be a crucial factor in H. pylori eradication success, and we therefore mapped these resistance patterns nationwide in Korea. Materials and Methods Five hundred and ninety adult subjects were prospectively enrolled from 2017 to 2018 from 15 centers across six geographic areas of Korea. A total of 580 biopsy tissues had been sampled from these patients during an upper endoscopy and were frozen at −80°C and delivered to a central laboratory. The agar dilution method was used to determine the minimum inhibitory concentration of amoxicillin, clarithromycin, metronidazole, tetracycline, ciprofloxacin, and levofloxacin for each H. pylori isolate. Results The culture success rate was 60.2% (349/580). Resistance rates against clarithromycin, metronidazole, amoxicillin, tetracycline, levofloxacin, and ciprofloxacin were 17.8%, 29.5%, 9.5%, 0%, 37.0%, and 37.0%, respectively. The geographic distribution of metronidazole and quinolone resistance was highly variable. Some subjects had multiple H. pylori strains in the antrum and body of the stomach and showed a heterogeneous resistance profile between these anatomic areas. The H. pylori multidrug resistance (MDR) rate was 25.2% (88/349) among amoxicillin, clarithromycin, metronidazole, tetracycline, and quinolone and 11.2% (39/349) among four of these major antibiotics except for quinolone. The Seoul and Chungcheong areas showed a relatively lower MDR rate. Conclusion The antibiotic resistance of H. pylori differs by drug and geographic area in Korea. Detailed nationwide antibiotic resistance mapping is needed to develop an effective H. pylori eradication strategy.
    Type of Medium: Online Resource
    ISSN: 1083-4389 , 1523-5378
    URL: Issue
    URL: Article
    DOI: 10.1111/hel.2019.24.issue-4
    DOI: 10.1111/hel.12592
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2020336-6
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  • 4
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    Effects of argon plasma coagulation on human stomach tissue: An ex vivo study
    Wiley ; 2017
    In:  Journal of Gastroenterology and Hepatology Vol. 32, No. 5 ( 2017-05), p. 1040-1045
    Details
    In: Journal of Gastroenterology and Hepatology, Wiley, Vol. 32, No. 5 ( 2017-05), p. 1040-1045
    Abstract: Argon plasma coagulation (APC) is a safe alternative treatment for gastrointestinal neoplasms and precancerous lesions. However, the extent of thermal damage after APC is difficult to predict. We investigated the effects of APC on human stomach tissue. Methods Argon plasma coagulation was performed on 10 freshly resected human stomachs that were obtained after total gastrectomy. The effects on tissue were compared across power settings (40, 60, and 80 W), durations (5, 10, 15, 20, and 25 s), and between injection (submucosal injection of normal saline) and control (without injection) groups. Success was defined as complete mucosal necrosis without damaging the muscularis propria. Results Without submucosal injection, the incidence of damaging the muscularis propria increased as the power and duration increased. Tissue damage in the injection group was mostly confined to the submucosa, even when using the high‐power setting. In the injection group, ablations at 40 W for 20 s, 60 W for 15 s, and 80 W for 15 or 20 s produced success rates ≥80%. In the control group, ablations at 60 W for 10 s, and 80 W for 5, or 10 s produced success rates ≥80%. The optimal energy levels to achieve complete mucosal and submucosal necrosis without damaging the muscularis propria were 800–1600 and 600–800 J in the injection and control groups, respectively. Conclusion Application of APC produces good results with a low risk of perforation.
    Type of Medium: Online Resource
    ISSN: 0815-9319 , 1440-1746
    URL: Issue
    URL: Article
    DOI: 10.1111/jgh.2017.32.issue-5
    DOI: 10.1111/jgh.13636
    Language: English
    Publisher: Wiley
    Publication Date: 2017
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  • 5
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    Novel endoscopic categorization for prediction of chemoradiotherapy response in locally advanced esophageal cancer
    Wiley ; 2018
    In:  Journal of Gastroenterology and Hepatology Vol. 33, No. 6 ( 2018-06), p. 1213-1219
    Details
    In: Journal of Gastroenterology and Hepatology, Wiley, Vol. 33, No. 6 ( 2018-06), p. 1213-1219
    Abstract: Preoperative chemoradiotherapy (CRT) followed by esophagectomy is a well‐known treatment modality for patients with locally advanced esophageal cancer (EC). This study developed an algorithm to predict pathological complete response (CR) in these patients using post‐CRT endoscopic category with biopsy and validated the proposed algorithm. Methods A retrospective review of 141 consecutive patients who completed preoperative CRT and underwent surgical resection for locally advanced EC was performed. The post‐CRT endoscopic findings of each patient were stratified into five categories. Results The distribution of post‐CRT endoscopic categories was significantly different between the pathological CR and non‐pathological CR groups ( P   〈  0.001). About 76.8% (73/95) of patients in category 0, 1, or 2 achieved pathological CR. In contrast, 91.3% (42/46) of endoscopic categories 3 and 4 patients did not achieve pathological CR. Sensitivity of post‐CRT biopsy was 11.1%. Therefore, an algorithm combining biopsy results and dichotomized post‐CRT endoscopic category (category 0, 1, or 2 vs category 3 or 4) was developed. The sensitivity, specificity, and accuracy in predicting pathological CR by the proposed algorithm were 64.8%, 95.9%, and 82.8%, respectively. In the multivariate analysis, the proposed algorithm remained a significant negative factor of survival ( P  〈  0.001). Conclusions Algorithm using post‐CRT endoscopic category with biopsy may help identify locally advanced EC patients who achieved pathological CR after preoperative CRT. Modalities to accurately detect subepithelial remnant EC may further aid in predicting pathological CR.
    Type of Medium: Online Resource
    ISSN: 0815-9319 , 1440-1746
    URL: Issue
    URL: Article
    DOI: 10.1111/jgh.2018.33.issue-6
    DOI: 10.1111/jgh.14055
    Language: English
    Publisher: Wiley
    Publication Date: 2018
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  • 6
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    Eradication rate of Helicobacter pylori reinfection in Korea: A retrospective study
    Wiley ; 2019
    In:  Journal of Gastroenterology and Hepatology Vol. 34, No. 10 ( 2019-10), p. 1696-1702
    Details
    In: Journal of Gastroenterology and Hepatology, Wiley, Vol. 34, No. 10 ( 2019-10), p. 1696-1702
    Abstract: Guidelines for selecting the eradication regimen for Helicobacter pylori reinfection remain unclear. This study aimed to evaluate the eradication rate of H. pylori reinfection in patients with a previous infection successfully eradicated with index triple therapy. Methods This was a single‐center, retrospective case–control study. A total of 10 468 H. pylori ‐ infected patients treated with proton‐pump inhibitor‐based triple eradication therapy at a tertiary medical institution between 2005 and 2016 were enrolled. We reviewed the medical records of the enrolled patients and compared the treatment outcomes in those with H. pylori reinfection after a successful eradication. Results H elicobacter pylori infection was successfully eradicated with the index triple therapy in 7770 patients (74.2%). Among 3567 patients followed up for 〉  1 year, H. pylori reinfection occurred in 420 (11.8%; 3.06% per person‐year) during a median follow‐up of 39.1 months (interquartile range, 23.5–58.7 months). Of these patients, 164 received eradication therapy for reinfection (triple therapy in 102 and quadruple therapy in 62) and had follow‐up data. Triple therapy showed an eradication rate of 78.4% for H. pylori reinfection, which was not significantly different from that of the index triple therapy ( P  = 0.394). Quadruple therapy for reinfection exhibited a better eradication rate (87.1%) than triple therapy but without statistical significance ( P  = 0.237). Conclusions Retreatment with triple therapy for H. pylori reinfection after successful eradication of prior infection showed comparable outcomes to the index triple therapy. Bismuth‐containing quadruple therapy for reinfection tended to have a better eradication rate than did triple therapy.
    Type of Medium: Online Resource
    ISSN: 0815-9319 , 1440-1746
    URL: Issue
    URL: Article
    DOI: 10.1111/jgh.v34.10
    DOI: 10.1111/jgh.14639
    Language: English
    Publisher: Wiley
    Publication Date: 2019
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  • 7
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    Seroprevalence of Helicobacter pylori in Korea: A multicenter, nationwide study conducted in 2015 and 2016
    Wiley ; 2018
    In:  Helicobacter Vol. 23, No. 2 ( 2018-04)
    Details
    In: Helicobacter, Wiley, Vol. 23, No. 2 ( 2018-04)
    Abstract: The Korean College of Helicobacter and Upper Gastrointestinal Research has studied Helicobacter pylori (H. pylori) prevalence since 1998 and found a dynamic change in its prevalence in Korea. The aim of this study was to determine the recent H. pylori prevalence rate and compare it with that of previous studies according to socioeconomic variables. Methods We planned to enroll 4920 asymptomatic Korean adults from 21 centers according to the population distribution of seven geographic areas (Seoul, Gyeonggi, Gangwon, Chungcheong, Kyungsang, Cholla, and Jeju). We centrally collected serum and tested H. pylori serum IgG using a chemiluminescent enzyme immunoassay. Results We analyzed 4917 samples (4917/4920 = 99.9%) from January 2015 to December 2016. After excluding equivocal serologic results, the H. pylori seropositivity rate was 51.0% (2414/4734). We verified a decrease in H. pylori seroprevalence compared with previous studies performed in 1998, 2005, and 2011 ( P  〈   .0001). The H. pylori seroprevalence rate differed by area: Cholla (59.5%), Chungcheong (59.2%), Kyungsang (55.1%), Jeju (54.4%), Gangwon (49.1%), Seoul (47.4%), and Gyeonggi (44.6%). The rate was higher in those older than 40 years (38.1% in those aged 30‐39 years and 57.7% in those aged 40‐49 years) and was lower in city residents than in noncity residents at all ages. Conclusions Helicobacter pylori seroprevalence in Korea is decreasing and may vary according to population characteristics. This trend should be considered to inform H. pylori ‐related policies.
    Type of Medium: Online Resource
    ISSN: 1083-4389 , 1523-5378
    URL: Issue
    URL: Article
    DOI: 10.1111/hel.2018.23.issue-2
    DOI: 10.1111/hel.12463
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2020336-6
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  • 8
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    Preventing esophageal strictures with steroids after endoscopic submucosal dissection in superficial esophageal neoplasm
    Wiley ; 2019
    In:  Journal of Digestive Diseases Vol. 20, No. 11 ( 2019-11), p. 609-616
    Details
    In: Journal of Digestive Diseases, Wiley, Vol. 20, No. 11 ( 2019-11), p. 609-616
    Abstract: This study aimed to investigate the efficacy of prophylactic steroid administration in preventing post‐endoscopic submucosal dissection (ESD) esophageal stricture and to determine risk factors for these strictures. Methods Patients who underwent ESD for superficial esophageal neoplasms with a mucosal defect affecting 〉 75% of the esophageal circumference between January 2011 and August 2016 were eligible. Patients were classified into three groups, including ESD‐alone group (n = 22), oral steroid group (n = 25) and intralesional steroid injection group (n = 6). Univariate and multivariate logistic regression analyses were performed to evaluate the risk factors for esophageal stricture. Results The stricture rate was 50.0%, 20.0% and 33.3% in the ESD‐alone group, oral steroid group and steroid injection group, respectively. Patients treated with steroids had a significantly lower stricture rate than the ESD‐alone group (22.6% vs 50.0%, P = 0.046). Additionally, oral steroid group had a significantly lower stricture rate than the ESD‐alone group ( P = 0.037). Multivariate analysis revealed that the extent of the circumferential mucosal defect was a significant risk factor for post‐ESD strictures (odds ratio [OR] 13.015, 95% confidence interval [CI] 2.257‐76.077, P = 0.004). The administration of steroids (OR 0.108, 95% CI 0.020‐0.578, P = 0.009), specifically oral steroids (OR 0.109, 95% CI 0.019‐0.622, P = 0.013), was associated with prevention of post‐ESD strictures. Conclusion Oral steroid prophylaxis appears to be a safe and effective treatment in preventing post‐ESD stricture and improving patients' quality of life.
    Type of Medium: Online Resource
    ISSN: 1751-2972 , 1751-2980
    URL: Issue
    URL: Article
    DOI: 10.1111/cdd.v20.11
    DOI: 10.1111/1751-2980.12819
    Language: English
    Publisher: Wiley
    Publication Date: 2019
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  • 9
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    The efficacy of a novel percutaneous endoscopic gastrostomy simulator using three‐dimensional printing technologies
    Wiley ; 2019
    In:  Journal of Gastroenterology and Hepatology Vol. 34, No. 3 ( 2019-03), p. 561-566
    Details
    In: Journal of Gastroenterology and Hepatology, Wiley, Vol. 34, No. 3 ( 2019-03), p. 561-566
    Abstract: We developed a novel training simulator for percutaneous endoscopic gastrostomy (PEG) and determined its efficacy and realism in PEG insertion training. Methods The gastrostomy simulator was made using three‐dimensional printing and silicone molding technology. The simulator is of two types: pull type and introducer type. We enrolled 20 participants, comprising 10 beginners with no experience of PEG insertion and 10 PEG‐experienced endoscopists. Each participant underwent two training sessions for the two simulator types. We recorded the simulation time, self‐evaluation, and difficulty score based on a 5‐score scale for PEG insertion among the participants. Subsequently, simulator performance was assessed via a questionnaire based on a 7‐point Likert scale. Results The mean time to completion of PEG simulation decreased from 11.9 (5.2) to 9.0 (4.0) min for the pull type and from 13.8 (7.0) to 12.0 (5.8) min for the introducer type in the beginner group. The mean self‐evaluation scores of beginners increased from 2.2 (1.1) to 3.1 (0.7) (pull type) and from 2.2 (1.2) to 3.3 (0.8) (introducer type). The mean procedure difficulty scores of beginners decreased from 3.4 (1.1) to 2.7 (0.9) (pull type) and from 4.4 (0.5) to 3.0 (0.8) (introducer type). The improvement of skill score was 6.3 (1.2) for the beginner group. The general realism score of the simulator for handling was judged to be 6.0 (0.9) by the experienced group. Conclusions The three‐dimensional‐printed simulator for PEG insertion can be useful for training of beginner endoscopists and shows good efficacy and realism.
    Type of Medium: Online Resource
    ISSN: 0815-9319 , 1440-1746
    URL: Issue
    URL: Article
    DOI: 10.1111/jgh.2019.34.issue-3
    DOI: 10.1111/jgh.14527
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2006782-3
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  • 10
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    Endoscopic prediction of recurrence in patients with early gastric cancer after margin‐negative endoscopic resection
    Wiley ; 2016
    In:  Journal of Gastroenterology and Hepatology Vol. 31, No. 7 ( 2016-07), p. 1284-1290
    Details
    In: Journal of Gastroenterology and Hepatology, Wiley, Vol. 31, No. 7 ( 2016-07), p. 1284-1290
    Abstract: Although follow‐up endoscopy is routinely performed after endoscopic resection (ER) for early gastric cancer (EGC), it remains unclear whether resection scar biopsies should also be taken. This study sought to predict local recurrence at the ER scar on the basis of endoscopic criteria after margin‐negative EGC resection and to determine the necessity of taking scar biopsies. Methods All consecutive patients with EGC who underwent margin‐negative ER in June 1995 to December 2011 and developed recurrence at the scar were identified. Each case was matched by four controls with EGC and margin‐negative ER but without local recurrence for age, sex, and en‐bloc resectability (en‐bloc vs . piecemeal resection). Endoscopic data were reviewed by consensus of two endoscopists. Key endoscopic criteria were gross morphology (evenly elevated, unevenly elevated, and flat), hyperemic change, mucosal defect, and spontaneous bleeding. Results Of 3037 cases, which underwent margin‐negative ER, 22 developed local recurrence (mean age, 63.8 years; 72.9% male). En‐bloc resection was achieved in 20 of the 22 (90.9%). Flat endoscopic morphology without hyperemic changes predicted non‐recurrence at the scar with a sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 95.5%, 68.2%, 2.6%, 99.94%, and 73.6%, respectively. For patients who underwent en‐bloc resection for differentiated EGC, these values were 100%, 71.4%, 3.0%, 100%, and 75.8%, respectively. Conclusions Routine follow‐up biopsies may be unnecessary when follow‐up endoscopy reveals flat mucosa without hyperemic changes at the scar, especially for en‐bloc resected and differentiated EGCs.
    Type of Medium: Online Resource
    ISSN: 0815-9319 , 1440-1746
    URL: Issue
    URL: Article
    DOI: 10.1111/jgh.2016.31.issue-7
    DOI: 10.1111/jgh.13301
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2006782-3
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