In:
The American Journal of Chinese Medicine, World Scientific Pub Co Pte Ltd, Vol. 43, No. 03 ( 2015-01), p. 425-441
Abstract:
As a treatment for allergic asthma, inhaled treatments such as bronchodilators that contain β 2 -agonists have an immediate effect, which attenuates airway obstructions and decreases airway hypersensitivity. However, bronchodilators only perform on a one off basis, but not consistently. Asthma is defined as a chronic inflammatory disease of the airways accompanying the overproduction of mucus, airway wall remodeling, bronchial hyperreactivity and airway obstruction. Liriope platyphylla radix extract (LPP), a traditional Korean medicine, has been thoroughly studied and found to be an effective anti-inflammatory medicine. Here, we demonstrate that an inhaled treatment of LPP can attenuate airway hyperresponsiveness (AHR) in an ovalbumin-induced asthmatic mouse model, compared to the saline-treated group (p 〈 0.01). Moreover, LPP decreases inflammatory cytokine levels, such as eotaxin (p 〈 0.05), IL-5 (p 〈 0.05), IL-13 (p 〈 0.001), RANTES (p 〈 0.01), and TNF-α (p 〈 0.05) in the bronchoalveolar lavage (BAL) fluid of asthmatic mice. A histopathological study was carried out to determine the effects of LPP inhalation on mice lung tissue. We performed UPLC/ESI-QTOF-MS, LC/MS, and GC/MS analyses to analyze the chemical constituents of LPP, finding that these are ophiopogonin D, spicatoside A, spicatoside B, benzyl alcohol, and 5-hydroxymethylfurfural. This study demonstrates the effect of an inhaled LPP treatment both on airway AHR and on the inflammatory response in an asthmatic mouse model. Hence, LPP holds significant promise as a nasal inhalant for the treatment of asthmatic airway disease.
Type of Medium:
Online Resource
ISSN:
0192-415X
,
1793-6853
DOI:
10.1142/S0192415X15500275
Language:
English
Publisher:
World Scientific Pub Co Pte Ltd
Publication Date:
2015
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